Adults

Researchers need people who are depressed to volunteer for a research study looking at the brain.

This research study is enrolling people to help us understand how physical activity, daily rhythms, and light affect mental health. 

Researchers are looking for healthy volunteers to help us learn more about how the brain works. We need to learn more about how the brain works so that we can learn more about how brains work in people with mood and anxiety disorders.

Several investigational studies are measuring proteins in the brain and body using Positron Emission Tomography (PET) technology to better understand the biological basis of mental illness and to eventually pave the way for new treatments.

Researchers are enrolling healthy volunteers for an outpatient research study to learn more about how the brain works.

Researchers need people who are depressed to volunteer for a research study looking at the brain.

Several research studies are measuring proteins in the brain using Positron Emission Tomography (PET) technology to better understand the biological basis of mental illness and to eventually pave the way for new treatments.

Researchers are testing a new type of investigational non-invasive brain stimulation to see if it is safe and potentially helpful to treat depression symptoms.

This study screens for various inpatient and outpatient studies that investigate the brain and experimental medications (such as ketamine) to quickly lift severe and hard-to-treat depressive symptoms.

This inpatient study is testing the effectiveness of an investigational new drug, HNK, which comes from ketamine.

This research study is trying to better understand how ketamine (an FDA-approved anesthetic) works to provide rapid antidepressant effects. Researchers want to see if the antidepressant response of ketamine is linked to a specific protein in the brain, called AMPA receptors, and if taking perampanel (an FDA-approved epilepsy medication) with ketamine weakens or eliminates its antidepressant response.

The purpose of this study is to evaluate the rapid and sustained antidepressant effects of repeated doses of ketamine in the brain. We want to learn how ketamine affects areas of the brain important in regulating mood and if there are unique signatures that could help predict who may respond to the drug. Also, we want to see if repeated doses of ketamine are safe and effective in treating the symptoms of depression.

This research study seeks depressed participants to test the effects of the combination of repetitive transcranial magnetic stimulation (TMS) and psychotherapy on brain function.

This research study seeks to understand how HIV infection affects the brain, moods, memory, thinking and concentration and how it may contribute to dementia and depression. Researchers will compare persons with and without HIV infection.

How we feel can impact the choices we make. Feelings of sadness, stress, or pain can change our behavior. Researchers want to learn more about the choices we make when feeling bad.

Researchers are looking for genes that may affect a person's chances of developing bipolar disorder. You can participate in this research study if you are over 18, have a bipolar diagnosis, or have a family member with bipolar disorder.

Researchers are enrolling healthy volunteers for an outpatient research study to learn about the brain. A part of the study evaluates how the brain activates and represents memories. Participants will watch videos created in the “1 Second Everyday App” during a brain scan (MRI) and again during a MEG (magnetoencephalography) scan.

Researchers are working to understand depression related to the menopause transition. This placebo controlled research study will test whether an experimental medication, Lily compound LY500307, can prevent depression that may occur after suddenly stopping Estrogen Therapy (ET). This drug acts like estrogen, but has a more limited range of effects.

People feel different levels of pain. These differences are caused by social, cultural, and biological factors. Researchers at the National Institutes of Health are trying to better understand the different factors that impact pain and how people experience pain.

The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.

Adults, ages 18 to 70, who are in good physical and mental health are invited to participate in this research study. The goal of the study is to create a list of pre-qualified research volunteers who would like to participate in additional NIMH studies at the NIH Clinical Center in Bethesda, Maryland. 

This is an observational study for perimenopausal depression in women between the ages of 40 and 60. The purpose of this study is to investigate mood and behavioral changes in the time period surrounding and including menopause.

Inflammation can play a role in diseases. Researchers are using whole-body positron emission tomography (PET) imaging to measure and detect the biomarkers of inflammation.

The purpose of this study is to identify and describe the symptoms of premenstrual syndrome (PMS).Women between the ages of 18 and 50 who experience PMS symptoms will be asked to complete clinical interviews, self-rating scales, and evaluations of mood. Your participation in this study will help researchers determine if you are eligible to participate in additional studies exploring the causes of, and treatment for PMS.

If you are a woman between 18 and 50 who experiences premenstrual syndrome (PMS), you may be eligible to help researchers investigate what causes it. This study explores possible causes of PMS by using a medication to stop the menstrual cycle temporarily. After the menstrual cycle is stopped, researchers will add back, in sequence, estrogen, and progesterone. The purpose of this study is to examine the influence of estrogen and progesterone on mood and behavior in women with PMS.

This part of the facial recognition study is enrolling healthy adults without psychiatric conditions, between the ages of 18 and 35, who are in good medical health, and have a bad memory for faces. The overall purpose of the study is to learn about the brain, thinking and memory in people with and without autism spectrum disorders.

National Institute of Mental Health (NIMH) researchers seek adults 18 to 70, who have a history of attempted suicide but are not currently suicidal, for a study of suicide and brain function. Participation includes up to seven days as an inpatient at the NIH Clinical Center in Bethesda, Maryland. Procedures include blood tests, medical evaluations, brain imaging, sleep studies and psychiatric interviews. Participants do not need to stop their current medications. Compensation and transportation are provided. Pregnant women and individuals with serious medical conditions are not eligible.

To learn more about what happens in the brain when someone has thought about or attempted suicide, researchers study a comparison group of people without suicidal thoughts.

How does brain activity impact transcranial magnetic stimulation (TMS) response? 

This research study seeks healthy adult participants to explore how transcranial magnetic stimulation (TMS) affects the brain. TMS is a non-invasive method which uses a magnet placed outside the head to stimulate precise locations inside the brain.

This research study seeks healthy adult participants to explore how transcranial magnetic stimulation (TMS) affects the brain. TMS is a non-invasive method which uses a magnet placed outside the head to stimulate precise locations inside the brain.

This research study will help all of us better understand behavior and mental health in children and young adults with Trisomy X. The study is currently enrolling children and young adults ages 6 to 25 with Trisomy X.

This research study seeks to compare persons without an HIV infection to those with the infection to understand how the infection may contribute to dementia and depression.

If you have ever suffered from postpartum depression (PPD) following childbirth, we would like you to call for information about participation in our study. The study is designed to determine if your PPD was caused by hormonal changes during or after pregnancy. This study will replicate a hormonal state of pregnancy and the 6-week period following delivery. Mood symptoms and hormone levels will be measured throughout the study.