Adults: Depression

Researchers need people who are depressed to volunteer for a research study looking at the brain.

This research study is enrolling people to help us understand how physical activity, daily rhythms, and light affect mental health. 

Researchers need people who are depressed to volunteer for a research study looking at the brain.

Researchers are testing a new type of investigational non-invasive brain stimulation to see if it is safe and potentially helpful to treat depression symptoms.

This study screens for various inpatient and outpatient studies that investigate the brain and experimental medications (such as ketamine) to quickly lift severe and hard-to-treat depressive symptoms.

This inpatient study is testing the effectiveness of an investigational new drug, HNK, which comes from ketamine.

This research study is trying to better understand how ketamine (an FDA-approved anesthetic) works to provide rapid antidepressant effects. Researchers want to see if the antidepressant response of ketamine is linked to a specific protein in the brain, called AMPA receptors, and if taking perampanel (an FDA-approved epilepsy medication) with ketamine weakens or eliminates its antidepressant response.

The purpose of this study is to evaluate the rapid and sustained antidepressant effects of repeated doses of ketamine in the brain. We want to learn how ketamine affects areas of the brain important in regulating mood and if there are unique signatures that could help predict who may respond to the drug. Also, we want to see if repeated doses of ketamine are safe and effective in treating the symptoms of depression.

This research study seeks depressed participants to test the effects of the combination of repetitive transcranial magnetic stimulation (TMS) and psychotherapy on brain function.

The major goal of this study is to examine how mood disorders, anxiety disorders and migraine run in families. We study both genetic and environmental factors that may contribute to these conditions.

National Institute of Mental Health (NIMH) researchers seek adults 18 to 70, who have a history of attempted suicide but are not currently suicidal, for a study of suicide and brain function. Participation includes up to seven days as an inpatient at the NIH Clinical Center in Bethesda, Maryland. Procedures include blood tests, medical evaluations, brain imaging, sleep studies and psychiatric interviews. Participants do not need to stop their current medications. Compensation and transportation are provided. Pregnant women and individuals with serious medical conditions are not eligible.