Adults: Perimenopause-Related Mood Disorders

Researchers are working to understand depression related to the menopause transition. This placebo controlled research study will test whether an experimental medication, Lily compound LY500307, can prevent depression that may occur after suddenly stopping Estrogen Therapy (ET). This drug acts like estrogen, but has a more limited range of effects.

This is an observational study for perimenopausal depression in women between the ages of 40 and 60. The purpose of this study is to investigate mood and behavioral changes in the time period surrounding and including menopause.