NIMH Virtual Workshop Agenda: Ultrasound Neuromodulation for Mental Health Applications
Meeting Chairs: Kim Butts Pauly, Ph.D., Lennart Verhagen, Ph.D.
NIMH Organizing Committee: Jessica Tilghman, Ph.D., Lizzy Ankudowich, Ph.D., Craig Fisher, Psy.D
Day 1
Introductory Remarks
12:00 p.m.
Sarah “Holly” Lisanby, M.D.
NIMH welcome
12:05 p.m.
Jessica Tilghman, Ph.D.
Workshop overview/goals
Session 1. Showcase
Moderator: Grace Hwang, Ph.D.
12:10 p.m.
Keith Murphy, Ph.D.
Remote Control of Brain Activity in Rodents
12:25 p.m.
Elsa Fouragnan, Ph.D.
Inducing Early Phase Neuroplasticity in Humans
12:40 p.m.
Q&A
Session 2. Biophysical Considerations
Moderator: Jean-François Aubry, Ph.D.
12:50 p.m.
Kim Butts Pauly, Ph.D.
Biophysical effects
1:25 p.m.
Jean-François Aubry, Ph.D.
Biophysical safety
2:00 p.m.
Q&A
2:10 p.m.
Kim Butts Pauly, Ph.D.
Elisa Konofagou, Ph.D.
Mark Schafer, Ph.D.
Matthew Myers, Ph.D.
Xiaorui Tang, Ph.D.
Panel Discussion
2:40 p.m.
Break
Session 3. Physiological and Clinical Considerations
Moderator: Lennart Verhagen, Ph.D.
3:00 p.m.
Shy Shoham, Ph.D.
Biomechanisms
3:25 p.m.
Lennart Verhagen, Ph.D.
Physiological safety
3:50 p.m.
Fidel Vila-Rodriguez, M.D., Ph.D.
Clinical safety in mental health therapy
4:15 p.m.
Q&A
4:25 p.m.
Ellen Bubrick, M.D.
Miriam Klein-Flügge, Ph.D.
Til Ole Bergmann, Ph.D.
Bin He, Ph.D.
Noah Philip, M.D.
Panel Discussion
4:55 p.m.
Adjourn
Day 2
12:00 p.m.
Lennart Verhagen, Ph.D.
Recap of Day 1
Session 4. The Regulatory Pathway for FUS Neuromodulation as a Treatment
Moderator: Matthew Myers, Ph.D.
12:10 p.m.
Pamela Scott, M.S.
Regulatory evaluation of FUS neuromodulation
12:35 p.m.
Q&A.
12:45 p.m.
Meijun Ye, Ph.D.
Anita Bajaj, M.D.
Pamela Scott, M.S.
Mark Carol, M.D.
Rhonda Robinson Beale, M.D.
Gerald Rogan, M.D.
Panel Discussion
Session 5. Experimental Planning and Design: Reaching the Target
Moderator: Bradley Treeby, Ph.D.
1:15 p.m.
Darin Dougherty, M.D.
Clinical Trial Design
1:35 p.m.
Bradley Treeby, Ph.D.
Modeling/targeting with and without subject-specific images
1:55 p.m.
Elly Martin, Ph.D.
Standardized metrology/calibration
2:15 p.m.
Q&A
2:25 p.m.
Elly Martin, Ph.D.
Elsa Fouragnan, Ph.D.
Charles Caskey, Ph.D.
Darin Dougherty, M.D.
Fidel Vila-Rodriguez, M.D., Ph.D.
Panel Discussion
2:55 p.m.
Break
Session 6. Optimizing Target Engagement: Parameter Space and Effects
Moderator: Lennart Verhagen, Ph.D.
3:15 p.m.
Sarah “Holly” Lisanby, M.D.
Targeting in the mental health space
3:30 p.m.
Li Min Chen, MD, Ph.D.
MRI for target engagement of acute effects
3:50 p.m.
Miriam Klein-Flügge, Ph.D.
Behavior and MRI for target engagement of delayed effects
4:10 p.m.
Tulika Nandi, Ph.D.
Parameter space
4:30 p.m.
Q&A
4:40 p.m.
Elsa Fouragnan, Ph.D.
Li Min Chen, M.D., Ph.D.
Tulika Nandi, Ph.D.
Miriam Klein-Flügge, Ph.D.
Til Ole Bergmann, Ph.D.
Panel Discussion
Synthesis, Opportunities, Next Steps, Closing Remarks
5:10 p.m.
Kim Butts Pauly, Ph.D.
Lennart Verhagen, Ph.D.
5:30 p.m.
Adjourn