Progress for Goal 1

Learn about the progress NIMH has made toward Goal 1 of the NIMH Strategic Plan for Research: Define the Brain Mechanisms Underlying Complex Behavior.

Brain Connectivity Linked With Cognition in People With Early Psychosis

An NIMH-funded study identified consistent links between brain connectivity and cognitive function in people with early stage psychosis and people at high risk who later developed psychosis.

Researchers Fully Map Neural Connections of the Fruit Fly Brain

A scientific team supported by the National Institutes of Health (NIH) unveiled the first complete map of the neural connections of the common fruit fly brain.

Youth With Conduct Disorder Show Widespread Differences in Brain Structure

The largest neuroimaging study of conduct disorder to date, with funding from NIH, has revealed extensive changes in brain structure among young people with the disorder. The largest difference was a smaller area of the brain’s outer layer, known as the cerebral cortex, which is critical for many aspects of behavior, cognition and emotion.

Noninvasively Stimulating Deep Brain Areas to Treat Depression Symptoms

In a new neuroimaging study funded by the National Institute of Mental Health, researchers used repetitive transcranial magnetic stimulation to target regions deep in the brain to help reduce depression symptoms.

Scientists Map Networks Regulating Gene Function in the Human Brain

An NIMH-funded research consortium has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders.

Understanding the Underpinnings of Sensory Hypersensitivity in SCN2A-Associated Autism

In this NIMH-supported study, researchers investigated the neural underpinnings of sensory hypersensitivity in SCN2A-associated autism.

Study Reveals Potential Neural Marker for Social Impairment in Psychotic Disorders

Research funded by NIMH found a link between a low level of social interest among people with psychotic disorders and brain regions in the social motivation system.

NIH Researchers Identify Brain Connections Associated With ADHD in Youth

Researchers at the National Institutes of Health (NIH) have discovered that symptoms of attention-deficit/hyperactivity disorder (ADHD) are tied to atypical interactions between the brain’s frontal cortex and information processing centers deep in the brain.

Researchers Expand Understanding of Genetic Mechanisms Underlying Fragile X Syndrome

An NIMH-supported study of the 3D genome revealed widespread silencing of genes with important roles in brain function in fragile X syndrome and related disorders.

Scientists Unveil Complete Cell Map of a Whole Mammalian Brain

For the first time ever, an international team of researchers has created a complete cell atlas of a whole mammalian brain.

Scientists Unveil Detailed Cell Maps of the Human Brain and the Nonhuman Primate Brain

A group of international scientists have mapped the genetic, cellular, and structural makeup of the human brain and the nonhuman primate brain, allowing for a deeper knowledge of the cellular basis of brain function and dysfunction, helping pave the way for a new generation of precision therapeutics for people with mental disorders and other disorders of the brain.

Researchers Solve the Puzzle of a Brain Receptor’s Activation

Researchers in a NIMH-supported study identified a new receptor for glycine that helps enhance communication between nerve cells in the brain and offers a potential new target for treating mental disorders.

Newly Discovered Brain Connection Affects Reward Behavior in Mice

NIMH-funded research sheds light on how negative early life experiences may impact how we act in response to rewards, which is often disrupted in people with mental illnesses.

Researchers Find Order in the Language of the Brain

New research supported by NIMH used mathematical approaches to explain how neurons in the brain communicate over time to support information processing.

Researchers Unlock Genetic Mutations Contributing to Disorders in the Brain

Researchers identified novel genes with mosaic mutations contributing to treatment-resistant pediatric epilepsy and pointing to specific disrupted pathways in cortical development.

NIMH Creates Publicly Accessible Resource With Data From Healthy Volunteers

The NIMH Healthy Research Volunteer Study aims to build a comprehensive, publicly accessible resource with a range of brain and behavioral data from healthy volunteers.

T Cells Help HIV Enter and Persist in the Brain

A recent NIMH-supported study sheds light on the role of a unique set of T cells in trafficking HIV infection into the brain and mediating the virus’ persistence there.

Researchers Map the Genetic Landscape of Schizophrenia in the Brain

In a comprehensive postmortem genetic analysis of the caudate nucleus in the brain, NIMH-supported researchers identified many genes associated with schizophrenia risk, including a gene that regulates the flow of the chemical messenger dopamine.

Rare Genetic Variation in 10 Genes Substantially Raise the Risk for Schizophrenia

In one of the largest genetic studies of its kind researchers funded by the National Institute of Mental Health identified variations in 10 genes that significantly raise the risk for schizophrenia—information that could help identify new treatment targets.

NIH BRAIN Initiative Launches Projects to Develop Cell Atlases and Molecular Tools for Cell Access

The National Institutes of Health has launched two transformative projects supported by the Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative: The BRAIN Initiative® Cell Atlas Network and the Armamentarium for Precision Brain Cell Access.

Tool Uses Light to Inhibit Neural Activity in Mice

Researchers supported by NIH have developed a way to genetically insert a type of light receptor into neurons. The new technique enables the researchers to suppress the neuron’s activity using pulses of light.

Autism and Congenital Heart Disease Share Underlying Molecular Network

A recent study of gene networks may hold some promising clues about shared mechanisms underlying autism spectrum disorder and congenital heart disease, two physiologically distinct disorders that often co-occur.

NIH BRAIN Initiative Unveils Detailed Atlas of the Mammalian Primary Motor Cortex

The NIH Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative Cell Census Network (BICCN) has unveiled an atlas of cell types and an anatomical neuronal wiring diagram for the mammalian primary motor cortex, derived from detailed studies of mice, monkeys, and humans.

Genomic Data From More Than 41,000 People Shed New Light on Bipolar Disorder

In the largest genome-wide association study of bipolar disorder to date, researchers found about twice as many genetic locations associated with bipolar disorder as reported in previous studies. These and other findings help improve our understanding of the biological origins of bipolar disorder.

Eating Disorder Behaviors Alter Reward Response in the Brain

A new NIMH-supported study found that eating disorder behaviors alter the brain’s reward response process and food intake control circuitry, which can reinforce the behaviors.

NIMH’s Dr. Andrea Beckel-Mitchener Named Deputy Director of NIH BRAIN Initiative

Andrea Beckel-Mitchener, Ph.D., has been named deputy director of the trans-NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative.

New Experiences Enhance Learning by Resetting Key Brain Circuit

A study of spatial learning in mice shows that exposure to new experiences dampens established representations in the brain’s hippocampus and prefrontal cortex, allowing the mice to learn new navigation strategies.

Gene Readouts Contribute To Distinctness of Mental Disorders

A new study conducted by researchers at NIMH suggests that differences in the expression of gene transcripts – readouts copied from DNA that help maintain and build our cells – may hold the key to understanding how mental disorders with shared genetic risk factors result in different patterns of onset, symptoms, course of illness, and treatment responses.

NIH-funded Study Sheds Light on Abnormal Neural Function in Rare Genetic Disorder

A genetic study has identified neuronal abnormalities in the electrical activity of cortical cells derived from people with a rare genetic disorder called 22q11.2 deletion syndrome.

Genetic Variations Highlight the Importance of Metabolic Processes in Anorexia

The need to identify effective targets for intervention in anorexia nervosa is pressing, as patient outcomes are often poor. An NIMH-funded genome-wide association study suggests that metabolic processes may play an important role in the disorder, offering a promising new avenue for investigation.

Study Shows Highly Reproducible Sex Differences in Aspects of Human Brain Anatomy

A scientific analysis of more than 2,000 brain scans found evidence for highly reproducible sex differences in the volume of certain regions in the human brain.

Brain Cells Can Harbor and Spread HIV Virus to the Body

Researchers funded by NIMH have found that astrocytes, a type of brain cell, can harbor HIV and then spread the virus to immune cells that traffic out of the brain and into other organs.

Large-Scale Genetics Study Sheds Light on Developmental Origins of Autism

Researchers were able to identify different types of rare genetic variations associated with autism spectrum disorder by analyzing data shared via the NIMH-funded Autism Sequencing Consortium.