News and Multimedia Featuring DTR
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Researchers Investigate Potential Treatment for Eliminating HIV from the Brain• Research HighlightIn a recent NIMH-funded study, researchers explored a potential new way of clearing HIV from the brain by testing a drug that targets a type of immune cell known as macrophages.
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Brain Connectivity Linked With Cognition in People With Early Psychosis• Research HighlightAn NIMH-funded study identified consistent links between brain connectivity and cognitive function in people with early stage psychosis and people at high risk who later developed psychosis.
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Digital Autism Screening Tool Could Enhance Early Identification• Research HighlightA tablet-based screening tool that analyzes children’s behavior in response to specific video clips shows promise for enhancing early autism screening, according to a study supported by NIMH.
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Noninvasively Stimulating Deep Brain Areas to Treat Depression Symptoms• Research HighlightIn a new neuroimaging study funded by the National Institute of Mental Health, researchers used repetitive transcranial magnetic stimulation to target regions deep in the brain to help reduce depression symptoms.
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Characterizing Childhood Irritability Across Ages and Stages• Research HighlightNIMH-supported research captures expressions of irritability across developmental stages via a clinically relevant measurement tool: the MAPS Temper Loss Scale.
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Accelerating Science to Improve Early Autism Screening• Feature StoryPersistent, collective efforts in the research community show how making early autism screening part of routine health care can support the well-being of children and families.
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Revolutionizing the Study of Mental Disorders• Feature StoryThe Research Domain Criteria Initiative (RDoC) represented a new way to conceptualize the study of mental illnesses. In celebration of NIMH's 75th Anniversary, we reflect on the beginning and progress of this initiative.
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Study Reveals Potential Neural Marker for Social Impairment in Psychotic Disorders• Research HighlightResearch funded by NIMH found a link between a low level of social interest among people with psychotic disorders and brain regions in the social motivation system.
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Using Games to Explore the Mind• Institute UpdateThe National Institute of Mental Health (NIMH) and the non-profit organization The Many Brains Project partnered with the National Institutes of Health (NIH) All of Us Research Program to adapt a series of new game-like tasks that are now part of the All of Us Research Program’s participant experience.
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Combined, High Maternal Stress and Prenatal COVID-19 Infection May Affect Attention Span in Infants• Media AdvisoryPrenatal COVID-19 infection increased the risk for impaired attention and delayed socioemotional and cognitive functioning among infants of mothers who experienced high psychosocial stress during their pregnancy.
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Workshop Day 2: Ultrasound Neuromodulation for Mental Health Applications• VideoWorkshop Day 2: Ultrasound Neuromodulation for Mental Health Applications
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Workshop Day 1: Ultrasound Neuromodulation for Mental Health Applications• VideoWorkshop Day 1: Ultrasound Neuromodulation for Mental Health Applications
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Technical Assistance Webinar: Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Clinical High Risk for Psychosis Clinical Trial Network (U01 Clinical Trial Required)• VideoThis technical assistance webinar was for prospective applicants of the Notice of Funding Opportunity: Accelerating Medicines Partnership® Schizophrenia: Clinical High Risk for Psychosis Clinical Trial Network.
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Mothers' Difficult Childhoods Impact Their Children’s Mental Health• Research HighlightIn this NIMH-funded study, researchers examined how trauma gets passed from one generation to the next.
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Population Study Finds Depression Is Different Before, During, and After Pregnancy• Research HighlightNew NIMH-funded research tracked population-level rates of postpartum depression among new mothers before, during, and after pregnancy.
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Infants’ Health Record Data May Improve Early Autism Screening• Research Highlight
Research supported by NIMH suggests that children’s health records may yield some promising insights that could improve the accuracy of early autism screening.
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Attention to Geometric Images May Offer Biomarker for Some Toddlers with Autism• Research HighlightAn NIMH-supported study shows that preference for geometric images may be robust enough to serve as a biomarker for identifying some young children with autism.
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COVID-19 Pandemic Associated With Worse Mental Health and Accelerated Brain Development in Adolescents• Research HighlightAn NIMH-supported study suggests that adolescents living through the COVID-19 pandemic may be experiencing more anxiety and depression symptoms and accelerated brain aging.
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Brief Cognitive Training May Extend the Antidepressant Effects of Ketamine• Research HighlightAn NIMH-supported study suggests that a brief self-association training program can extend the effects of a single ketamine infusion by shifting people’s negative self-beliefs.
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Researchers Map the Genetic Landscape of Schizophrenia in the Brain• Research HighlightIn a comprehensive postmortem genetic analysis of the caudate nucleus in the brain, NIMH-supported researchers identified many genes associated with schizophrenia risk, including a gene that regulates the flow of the chemical messenger dopamine.
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NIH Announces Winners of High School Mental Health Essay Contest• Institute UpdateThe National Institutes of Health (NIH) is pleased to announce the winners of 2022 Speaking Up About Mental Health! This Is My Story essay contest.
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NIH Awards $100 Million for Autism Centers of Excellence Program• Institute UpdateThe National Institutes of Health has awarded a total of $100 million over the next five years to support nine Autism Centers of Excellence. This endeavor funds large research projects to understand and develop interventions for autism spectrum disorder.
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Toddlers’ Responses to “Baby Talk” Linked to Social, Cognitive, Language Abilities• Research HighlightIn an NIMH-supported study, researchers found that toddlers respond to emotionally expressive speech in different ways, and these varied responses are linked with their social, linguistic, and cognitive abilities.
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Low Motivation for Social Bonding May Signal Behavior Problems in Early Childhood• Research HighlightIn an NIMH-supported study, researchers found that low social affiliation—low motivation for social engagement and bonding—may be a precursor that identifies children as early as age 2 who are likely to develop callous-unemotional behaviors.
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Adult “Picky Eaters” Recall Helpful Parent Feeding Strategies• Research HighlightResearchers asked a group of self-identified adult “picky eaters” to reflect on their parents’ feeding strategies to better understand which strategies were helpful and which weren’t.
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Feelings of Detachment After Trauma May Signal Worse Mental Health Outcomes• Research HighlightA new NIMH-supported study shows that experiencing persistent feelings of detachment following trauma is an early psychological and biological marker of worse mental health outcomes.
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New Approach Allows Magnetic Brain Stimulation to Target Deep Brain Structures• Research HighlightTMS can only directly stimulate the outermost layer of the brain, but NIMH researchers have found that mapping a person’s brain architecture may make it possible to guide TMS to deep brain targets.
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Personalizing Deep Brain Stimulation for Treatment-Resistant Depression• Research HighlightA recent NIMH-supported study investigated whether deep brain stimulation could be personalized for individuals with treatment-resistant depression.
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Women’s Experiences of Sexual Assault and Harassment Linked With High Blood Pressure• Press ReleaseWomen who had ever experienced sexual violence in their lifetime—including sexual assault and workplace sexual harassment—were more likely to develop high blood pressure over a seven-year follow-up period, according to an NIH-funded study.
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Machine Learning Study Sheds Light on Gaze Patterns in Adults With Autism• Research HighlightNIMH researchers examine what people with ASD and people without ASD look at when viewing a social scene.
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Understanding the Characteristics of Suicide in Young Children• Research HighlightResearchers supported by NIMH recently published a study describing the characteristics of suicide in young children and the factors that sometimes precede these tragic events, providing an avenue for future research and intervention.
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Brain Activity Patterns After Trauma May Predict Long-Term Mental Health• Press ReleaseThe way a person’s brain responds to stress following a traumatic event, such as a car accident, may help to predict their long-term mental health outcomes, according to NIMH-supported research.
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Workshop on Advanced Statistical Methods and Dynamic Data Visualizations for Mental Health Studies: Day Two• VideoDay Two - NIMH conducted a two-day workshop on Advanced Statistical Methods and Dynamic Data Visualizations for Mental Health Studies.
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Workshop on Advanced Statistical Methods and Dynamic Data Visualizations for Mental Health Studies: Day One• VideoDay One - NIMH conducted a two-day workshop on Advanced Statistical Methods and Dynamic Data Visualizations for Mental Health Studies.
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NIMH Addresses Critical Need for Rapid-Acting Interventions for Severe Suicide Risk• Research HighlightNIMH is working to meet the urgent need for rapid-acting suicide prevention interventions by supporting research investigating the feasibility and safety of treatment protocols that have the potential to quickly reduce severe suicide risk in youth and adults.
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Testing and Refining Biomarkers to Support Intervention Research for Children with Autism• Research HighlightNIMH, along with other NIH Institutes, is supporting the ABC-CT project, a multisite study that aims to test and refine biomarkers that can be used as objective measures of social impairment for children with autism in clinical trials, leading to more predictive and personalized treatment.
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Social Disconnection and Late-Life Suicide: Mechanisms, Treatment Targets, and Interventions - Day Two• VideoOn September 17 and 18, 2020, the NIMH Division of Translational Research conducted a two-day virtual workshop, “Social Disconnection and Late Life Suicide,” which brought together clinician scientists, behavioral scientists, neuroscientists, geriatric psychiatrists, epidemiologists, and implementation scientists to discuss the current state of the science on social disconnection and suicide.
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Social Disconnection and Late-Life Suicide: Mechanisms, Treatment Targets, and Interventions - Day One, Part One• VideoOn September 17 and 18, 2020, the NIMH Division of Translational Research conducted a two-day virtual workshop, “Social Disconnection and Late Life Suicide,” which brought together clinician scientists, behavioral scientists, neuroscientists, geriatric psychiatrists, epidemiologists, and implementation scientists to discuss the current state of the science on social disconnection and suicide.
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Social Disconnection and Late-Life Suicide: Mechanisms, Treatment Targets, and Interventions - Day One, Part Two• VideoOn September 17 and 18, 2020, the NIMH Division of Translational Research conducted a two-day virtual workshop, “Social Disconnection and Late Life Suicide,” which brought together clinician scientists, behavioral scientists, neuroscientists, geriatric psychiatrists, epidemiologists, and implementation scientists to discuss the current state of the science on social disconnection and suicide.
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NIMH Director’s Statement on Racism• Institute Update
Right now, people across the country are currently coping with yet another episode of violence perpetrated against a person of color. In this Institute Update, Dr. Gordon addresses recent events.
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Supporting the Development of Early Autism Screening Tools• Research HighlightNIMH, along with other NIH Institutes, is supporting the goal of identifying autism in the first year of life by funding projects that seek to seek to translate findings related to early-emerging signs of autism into practical ASD screening tools that can be implemented in the general population and community settings.
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Virtual Workshop: Transforming the Practice of Mental Health Care• VideoOn April 2, NIMH convened a virtual workshop that brought together mental health leaders and experts from different fields to think through where there may be opportunities to leverage research and existing resources to transform the mental health care landscape.
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Combined Electroconvulsive Therapy and Venlafaxine a Well-Tolerated Depression Treatment for Older Adults• Research HighlightThe use of right unilateral ultrabrief pulse (RUL-UB) electroconvulsive therapy (ECT) in combination with the antidepressant venlafaxine to treat depression in elderly patients is well tolerated and results in minimal neurocognitive side effects, according to a new NIH-funded study published in the American Journal of Geriatric Psychiatry.
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Using Technology to Help Predict Binge and Purge Episodes in People with Eating Disorders• Research HighlightIn binge-eating disorder and bulimia nervosa, people experience recurrent and frequent episodes in which they eat unusually large amounts of food and feel a sense of loss of control.
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Neural Signature Identifies People Likely to Respond to Antidepressant Medication• Press ReleaseNIH-funded research uses machine learning algorithm to predict individual response to a commonly-prescribed antidepressant.
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NIH Awards Funding for Early Autism Screening• Institute Update
The National Institutes of Health (NIH) has awarded more than four million dollars in FY 2019 to support seven research projects aimed at developing and validating screening tools to detect signs of autism spectrum disorder in the first year of life.
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Brain Biomarkers Could Help Identify Those at Risk of Severe PTSD• Press ReleaseThis study has shed light on the neurocomputational contributions to the development of post-traumatic stress disorder in combat veterans, finding distinct patterns for how the brain and body respond to learning danger and safety depending on the severity of PTSD symptoms.
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Hyperconnectivity in a Brain Circuit May Predict Psychosis• Science UpdateNIMH-funded scientists have discovered a pattern in the way a brain circuit works that may help predict the onset of psychosis. High levels of chatter, or “hyperconnectivity,” in a circuit involving the cerebellum, thalamus, and cortex emerged as a potential “neural signature” in a functional magnetic resonance imaging (fMRI) study.
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Mood Stabilizing Medications an Effective Option for Older Adults with Bipolar Disorder• Science UpdateTwo standard medications for bipolar disorder were effective in controlling symptoms at doses tailored to older people in a clinical trial of treatment in adults over age 60.
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Imaging Pinpoints Brain Circuits Changed by PTSD Therapy• Science UpdateUsing brain imaging to track the effects of treatment of post-traumatic stress disorder (PTSD), scientists have identified a brain circuit on which a frequently used and effective psychotherapy (prolonged exposure) acts to quell symptoms. The findings help explain why the neural circuit identified is a promising target for additional treatment development, including brain stimulation therapies.
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NIMH Grantee Wins One of Science’s Most Coveted Prizes• Science UpdateNIMH grantee Karl Deisseroth, M.D., Ph.D., of Stanford University, has been awarded one of science’s most generous prizes. A German foundation presented the inventor of technologies that are transforming neuroscience with its 4 million euros Fresenius Prize.
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Brain “Relay” Also Key to Holding Thoughts in Mind• Press ReleaseLong overlooked as a mere “relay,” an egg-like structure in the middle of the brain also turns out to play a pivotal role in tuning-up thinking circuity. A trio of studies in mice are revealing that the thalamus sustains the ability to distinguish categories and hold thoughts in mind. It might even become a target for interventions for psychiatric disorders marked by working memory problems, such as schizophrenia.
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NIMH-Funded Study to Track the Effects of Trauma• Science Update
By carefully tracking 5,000 people after they have experienced a traumatic event, a just-launched NIMH-funded study aims to provide a finely detailed map of the array of factors that play a role in the development of mental disorders that occur in the wake of trauma.
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Biomarkers Outperform Symptoms in Parsing Psychosis Subgroups• Press ReleaseThree biomarker-based categories, called “biotypes,” outperformed traditional diagnoses, such as schizophrenia and bipolar disorder with psychosis, in sorting psychosis cases into distinct subgroups on the basis of brain biology
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NIH Joins Public-Private Partnership to Fund Research on Autism Biomarkers• Press ReleaseJames McPartland, Ph.D. of Yale University will lead a new four-year $28 million Biomarkers Consortium project that aims to improve clinical evaluation of treatments for social impairment in children with autism.
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Lisanby Chosen to Lead NIMH Division of Translational Research• Science UpdateDr. Sarah Hollingsworth Lisanby, one of the leading researchers in the area of neuromodulatory interventions for treating major depression, will join NIMH as the director of the Division of Translational Research.
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Earliest Marker for Autism Found in Young Infants• Press ReleaseEarliest Marker for Autism Found in Infants
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New Data Reveal Extent of Genetic Overlap Between Major Mental Disorders• Press ReleaseThe largest genome-wide study of its kind has determined how much five major mental illnesses are traceable to the same common inherited genetic variations.
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Long-term Course of ADHD Diagnosed in Preschool Years Can be Chronic and Severe• Science UpdateLong-term Course of ADHD Diagnosed in Preschool Years Can be Chronic and Severe
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Newly Awarded Autism Centers of Excellence to Further Autism Research• Press Release
The National Institutes of Health (NIH) announced on April 1, 2008, the latest recipients of the Autism Centers of Excellence (ACE) program.