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Transforming the understanding
and treatment of mental illnesses.

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Declarative Memory

RDoC Classification

Domain: Cognitive Systems

Description

Declarative memory is the acquisition or encoding, storage and consolidation, and retrieval of representations of facts and events. Declarative memory provides the critical substrate for relational representations—i.e., for spatial, temporal, and other contextual relations among items, contributing to representations of events (episodic memory) and the integration and organization of factual knowledge (semantic memory). These representations facilitate the inferential and flexible extraction of new information from these relationships.

Molecules

GlutamateNorepinephrineOpioid

Cells

GliaGranule cellsInhibitory and excitatory interneuronsPyramidal cells

Circuits

Extrinsic hippocampal circuitryIntrinsic hippocampal circuitryPFC and PPC interactions with multiple association cortices

Physiology

AMPA-related synaptic plasticityconjunction codesfrontal/temporal coordinated oscillationsLTP/LTDNMDA-related synaptic plasticityplace cell activitysubsequent memory effect (fMRI, ERP)up/down states

Behavior

DiscriminationFamiliarityLearningRecallRecognition

Self-Report

Cognitive Assessment Interview

Paradigms

acquired equivalencedelayed recalllist and story learningPaired associate learningtransitive inference