Select Publications

Light Affects Mood and Learning through Distinct Retina-Brain Pathways. 
Fernandez DC, Fogerson PM, Lazzerini Ospri L, Thomsen MB, Layne RM, Severin D, Zhan J, Singer JH, Kirkwood A, Zhao H, Berson DM, Hattar S.
Cell. 2018 Aug 23. pii: S0092-8674(18)31020-1. doi: 10.1016/j.cell.2018.08.004.

Eye-Drops for Activation of DREADDs. 
Keenan WT, Fernandez DC, Shumway LJ, Zhao H, Hattar S.
Front Neural Circuits. 2017 Nov 23;11:93. doi: 10.3389/fncir.2017.00093. eCollection 2017.

A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice. 
Chew KS, Renna JM, McNeill DS, Fernandez DC, Keenan WT, Thomsen MB, Ecker JL, Loevinsohn GS, VanDunk C, Vicarel DC, Tufford A, Weng S, Gray PA, Cayouette M, Herzog ED, Zhao H, Berson DM, Hattar S.
Elife. 2017 Jun 15;6. pii: e22861. doi: 10.7554/eLife.22861.

Mood, the Circadian System, and Melanopsin Retinal Ganglion Cells. 
Lazzerini Ospri L, Prusky G, Hattar S.
Annu Rev Neurosci. 2017 Jul 25;40:539-556. doi: 10.1146/annurev-neuro-072116-031324. Epub 2017 May 17. Review.

C-terminal phosphorylation regulates the kinetics of a subset of melanopsin-mediated behaviors in mice. 
Somasundaram P, Wyrick GR, Fernandez DC, Ghahari A, Pinhal CM, Simmonds Richardson M, Rupp AC, Cui L, Wu Z, Brown RL, Badea TC, Hattar S, Robinson PR.
Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2741-2746. doi: 10.1073/pnas.1611893114. Epub 2017 Feb 21.

A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction. 
Keenan WT, Rupp AC, Ross RA, Somasundaram P, Hiriyanna S, Wu Z, Badea TC, Robinson PR, Lowell BB, Hattar SS.
Elife. 2016 Sep 26;5. pii: e15392. doi: 10.7554/eLife.15392.

Architecture of retinal projections to the central circadian pacemaker. 
Fernandez DC, Chang YT, Hattar S, Chen SK.
Proc Natl Acad Sci U S A. 2016 May 24;113(21):6047-52. doi: 10.1073/pnas.1523629113. Epub 2016 May 9.

Light as a central modulator of circadian rhythms, sleep and affect. 
LeGates TA, Fernandez DC, Hattar S.
Nat Rev Neurosci. 2014 Jul;15(7):443-54. doi: 10.1038/nrn3743. Epub 2014 Jun 11. Review.

A role for melanopsin in alpha retinal ganglion cells and contrast detection. 
Schmidt TM, Alam NM, Chen S, Kofuji P, Li W, Prusky GT, Hattar S.
Neuron. 2014 May 21;82(4):781-8. doi: 10.1016/j.neuron.2014.03.022.

Recurrent axon collaterals of intrinsically photosensitive retinal ganglion cells. 
Joo HR, Peterson BB, Dacey DM, Hattar S, Chen SK.
Vis Neurosci. 2013 Jul;30(4):175-82. doi: 10.1017/S0952523813000199. Epub 2013 Jul 9.

Apoptosis regulates ipRGC spacing necessary for rods and cones to drive circadian photoentrainment. 
Chen SK, Chew KS, McNeill DS, Keeley PW, Ecker JL, Mao BQ, Pahlberg J, Kim B, Lee SC, Fox MA, Guido W, Wong KY, Sampath AP, Reese BE, Kuruvilla R, Hattar S.
Neuron. 2013 Feb 6;77(3):503-15. doi: 10.1016/j.neuron.2012.11.028.

Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. 
LeGates TA, Altimus CM, Wang H, Lee HK, Yang S, Zhao H, Kirkwood A, Weber ET, Hattar S.
Nature. 2012 Nov 22;491(7425):594-8. doi: 10.1038/nature11673. Epub 2012 Nov 14.

Intrinsically photosensitive retinal ganglion cells: many subtypes, diverse functions. 
Schmidt TM, Chen SK, Hattar S.
Trends Neurosci. 2011 Nov;34(11):572-80. doi: 10.1016/j.tins.2011.07.001. Epub 2011 Aug 3. Review.

Development of melanopsin-based irradiance detecting circuitry. 
McNeill DS, Sheely CJ, Ecker JL, Badea TC, Morhardt D, Guido W, Hattar S.
Neural Dev. 2011 Mar 18;6:8. doi: 10.1186/1749-8104-6-8.

Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities. 
Altimus CM, Güler AD, Alam NM, Arman AC, Prusky GT, Sampath AP, Hattar S.
Nat Neurosci. 2010 Sep;13(9):1107-12. doi: 10.1038/nn.2617. Epub 2010 Aug 15.

Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. 
Ecker JL, Dumitrescu ON, Wong KY, Alam NM, Chen SK, LeGates T, Renna JM, Prusky GT, Berson DM, Hattar S.
Neuron. 2010 Jul 15;67(1):49-60. doi: 10.1016/j.neuron.2010.05.023.

Retina-clock relations dictate nocturnal to diurnal behaviors. 
McNeill DS, Altimus CM, Hattar S.
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12645-6. doi: 10.1073/pnas.0806878105. Epub 2008 Aug 27. No abstract available.

Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision. 
Güler AD, Ecker JL, Lall GS, Haq S, Altimus CM, Liao HW, Barnard AR, Cahill H, Badea TC, Zhao H, Hankins MW, Berson DM, Lucas RJ, Yau KW, Hattar S.
Nature. 2008 May 1;453(7191):102-5. doi: 10.1038/nature06829. Epub 2008 Apr 23.

Central projections of melanopsin-expressing retinal ganglion cells in the mouse. 
Hattar S, Kumar M, Park A, Tong P, Tung J, Yau KW, Berson DM.
J Comp Neurol. 2006 Jul 20;497(3):326-49.