Information on Clinical Studies for Patients and Families
Is a Clinical Study the Right Fit for Your Child?
Children go through many phases of development. It can be hard to know if a child’s behavior is a result of normal development or if it’s a sign of something more serious. Occasional outbursts are a normal outcome of being tired, uncomfortable, or frustrated. In some children, these outbursts can be chronic and explosive.
If you feel like you’re constantly walking on eggshells around your child, the study on irritability may be right for your child. Children who enroll in our studies have irritability that significantly affects how they function at home, in school, and with other children.
View the brochures below to learn more about both studies.
Are you walking on eggshells around your irritable child?
CRANKY, GRUMPY, MOODY, FRUSTRATED, ANGRY
NIH RESEARCH STUDIES:
Enrolling Children and Adolescents Ages 8 to 17
JOIN A STUDY AT NIH: Children who enroll in our studies have irritability that significantly impacts their functioning at home, in school, and with other children. Eligible children may be offered a diagnostic assessment, a new approach to cognitive behavioral therapy, or non-treatment research options. Child can remain on current medications. Parents and child must agree to the child’s participation.
Eligible children with an ADHD diagnosis may participate as a comparison group in the non-treatment options.
Do you have a child with ADHD?
NIH research study ages 8 to 17
Eligible children may JOIN A STUDY that describes the moods and behaviors of children with an ADHD diagnosis, and investigates brain function and irritability.
Participation includes interviews, research testing, and brain imaging scans conducted over one to ten outpatient visits. Child can remain on current medications. Children must be medically healthy and not currently suicidal, psychotic, or hospitalized. Parents and child must agree to child’s participation.
This study is comparing attention-deficit/hyperactivity disorder (ADHD) to severe irritability in children. There is no cost to participate. Compensation is provided.
Disruptive mood dysregulation disorder (DMDD) is a condition in which children or adolescents experience ongoing irritability, anger, and frequent, intense temper outbursts. Our lab is studying and developing treatments for children with DMDD.
A clinical research study is often called a clinical trial or a protocol. Children must meet the study’s eligibility requirements, and parent and child must consent to participant in a study. Learn more about Clinical Trials at NIMH.
What Types of Studies does NNT conduct?
Observational Study
1-day outpatient (onsite or virtual) evaluation
Study describes moods and behaviors
Up to 10 follow-up visits (onsite or virtual) that include diagnostic assessments, questionnaires, mobile phone apps, computer tasks and brain imaging
Cognitive Behavioral Therapy (CBT)
12 therapy sessions and 20 weeks of evaluation
Child remains on current medications
Evaluate techniques and strategies to manage and modify irritability and disruptive behavior
Will also use technology such as mobile phones to assist with treatment
Childhood Irritability Newsletter
The Spring 2023 issue of the Childhood Irritability Newsletter includes research updates, community outreach news, a brain facts quiz, team member highlights, and more.
The Spring 2022 issue of the Childhood Irritability Newsletter includes CBT for irritability updates, team member highlights, Covid-19 research study findings, resources for parents, and more.
The Spring 2021 issue of the Childhood Irritability Newsletter includes information about CBT and irritability, the CALM-IT mobile app, Covid-19 health and safety updates, book resources for parents, and more.
Melissa A. Brotman, PhD
Chief, Neuroscience and Novel Therapeutics Unit Emotion and Development Branch
National Institute of Mental Health
9000 Rockville Pike, Building 15K
Bethesda, Maryland 20892 brotmanm@mail.nih.gov
Phone: (301) 435-6645