News and Multimedia Featuring IRP
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New Hope for Rapid-Acting Depression Treatment• Research HighlightA new study, funded in part by the National Institute of Mental Health, showed that a new medication derived from ketamine is safe and acceptable for use in humans, setting the stage for clinical trials testing it for hard-to-treat mental disorders like severe depression.
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Getting to the NIH Clinical Center• VideoHere is a video to help you get to your appointment on the NIH campus in Bethesda, Maryland.
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Increases Found in Preteen Suicide Rate• Media AdvisoryResearchers at the National Institutes of Health (NIH) found that rates of preteen suicide (ages 8-12) have been increasing by approximately 8% annually since 2008.
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Youth With Conduct Disorder Show Widespread Differences in Brain Structure• Press ReleaseThe largest neuroimaging study of conduct disorder to date, with funding from NIH, has revealed extensive changes in brain structure among young people with the disorder. The largest difference was a smaller area of the brain’s outer layer, known as the cerebral cortex, which is critical for many aspects of behavior, cognition and emotion.
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Basic Research Powers the First Medication for Postpartum Depression• Feature StoryDecades of NIMH-supported basic research led to a pioneering treatment for postpartum depression and continues to power exciting advances in women's mental health care.
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Novel Treatment Helps Children With Severe Irritability• Research HighlightA new study by NIMH researchers demonstrated the effectiveness, feasibility, and safety of exposure-based cognitive behavioral therapy for severe irritability and temper outbursts in children. The positive results set the foundation to continue exploring exposure therapy as a potential treatment for childhood irritability.
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NIH Researchers Identify Brain Connections Associated With ADHD in Youth• Media AdvisoryResearchers at the National Institutes of Health (NIH) have discovered that symptoms of attention-deficit/hyperactivity disorder (ADHD) are tied to atypical interactions between the brain’s frontal cortex and information processing centers deep in the brain.
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Cognitive Behavioral Therapy Alters Brain Activity in Children With Anxiety• Press ReleaseResearchers at the National Institute of Mental Health found that unmedicated children with anxiety disorders show widespread overactivation in brain functioning and that treatment with cognitive behavioral therapy led to a clinically significant drop in anxiety symptoms and improved brain functioning.
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Disparities in Psychotic Disorder Diagnoses and Other Negative Health Outcomes• Research HighlightNIMH researchers found racial and ethnic disparities in rates of psychotic disorders, which were associated with co-occurring medical conditions and negative health outcomes.
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Isabel Wilder, Winner of the 2023 NIMH Three-Minute Talks Competition• VideoIsabel Wilder discusses white matter is made up of myelinated nerve tracts and acts as a relay coordinating communications between brain regions. Myelin is a protective sheath composed of fatty lipids, which greatly enhance the efficiency of these communications. And in fact, this myelin is what makes white matter in the human brain appear white.
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Destiny Wright, Winner of the 2023 NIMH Three-Minute Talks Competition• VideoDestiny Wright discusses working memory can be thought of as the brain’s sticky notes allowing us to briefly hold and manipulate information. We use it to plan and carry out everyday tasks, such as making a list of chores or remembering bedtime routines, which as we know are things that young children really struggle with.
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Annie Ilsley, Winner of the 2023 NIMH Three-Minute Talks Competition• VideoAnnie Ilsley discusses white matter composes about half the brain and forms pathways that are essential for communication between regions. Myelination is a key, neurodevelopmental process in which a fatty sheath, known as myelin, envelops neuronal axons that form white matter tracks, acting as insulation and allowing for efficient conduction through these pathways.
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Alaina Tillman, Winner of the 2023 NIMH Three-Minutes Talks Competition• VideoAlaina Tillman discusses psychiatry is moving toward a precision medicine model. For patients diagnosed with depression, selective serotonin re-uptake inhibitors, SSRIs, are the most common treatment administered. However, for SSRIs, only about half of patients experience a relief of symptoms.
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Cracking the Ketamine Code• Feature StoryNIMH supported science and NIMH researchers helped pave the way for the development of ketamine—a groundbreaking treatment that has improved the lives of those who are impacted by treatment-resistant depression.
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The Center for Global Mental Health Research Webinar Series 2023: Real-World Opportunities and Challenges: Using NIMH's Research Domain Criteria (RDoC) Framework in Global Mental Health Research• VideoThis webinar discussed the National Institute of Mental Health’s Research Domain Criteria (RDoC) initiative and its potential to inform (and be informed by) global mental health research. RDoC is a research framework that encourages the investigation of mental disorders from a perspective of basic functional dimensions (e.g., cognitive control), using many types of information – from genomics and neuroscience to behavior and environmental measures.
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Facebook Live: Youth Suicide Prevention• VideoIn recognition of National Suicide Prevention Awareness Month in September, the National Institute of Mental Health (NIMH) hosted a Facebook Live event on youth suicide prevention.
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Researchers Find Order in the Language of the Brain• Research HighlightNew research supported by NIMH used mathematical approaches to explain how neurons in the brain communicate over time to support information processing.
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Youth Suicide Rates Increased During the COVID-19 Pandemic• Research HighlightIn one of the first studies to examine national youth suicide rates during the COVID-19 pandemic, researchers showed that the pandemic increased youth suicide rates and the impact varied by sex, age, and race and ethnicity.
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Facebook Live: Understanding Schizophrenia• VideoIn recognition of Mental Health Awareness Month, NIMH conducted a Facebook Live on schizophrenia.
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Facebook Live: Bipolar Disorder in Adults• VideoIn recognition of World Bipolar Day, NIMH experts conducted a Facebook Live event on bipolar disorder in adults.
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Abby Vogeley, Winner of the 2022 NIMH Three-Minute Talks Competition• VideoAbby Vogeley discusses the long-term observation of participants with treatment resistant mood disorders to understand their current treatment utilization and symptom severity. Topics: depression
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Lanie Bachmann, Winner of the 2022 NIMH Three-Minute Talks Competition• VideoLanie Bachmann discusses how different emotional expressions capture your attention and whether anxiety may act as a modulating factor through an online visual search experiment. Topics: Anxiety
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Taylor Drazan, Winner of the 2022 NIMH Three-Minute Talks Competition• VideoTaylor Drazan Taylor Drazan discusses the role that pregnancy plays in brain alterations, hormone levels, and behavior in the Common marmoset. Topics: Women’s mental health
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NIMH Creates Publicly Accessible Resource With Data From Healthy Volunteers• Research HighlightThe NIMH Healthy Research Volunteer Study aims to build a comprehensive, publicly accessible resource with a range of brain and behavioral data from healthy volunteers.
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2022 High Throughput Imaging Characterization of Brain Cell Types & Connectivity-Day 2, Part 1• VideoThe purpose of this NIH BRAIN Initiative workshop was to discuss unmet needs and emerging imaging approaches to characterizing brain cell types and their connectivity in human and other mammalian brains, in parallel with the BRAIN Initiative funding opportunity announcements (RFA-MH-22-290, RFA-MH-22-291, RFA-MH-22-292).
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2022 High Throughput Imaging Characterization of Brain Cell Types & Connectivity-Day 2, Part 2• VideoThe purpose of this NIH BRAIN Initiative workshop was to discuss unmet needs and emerging imaging approaches to characterizing brain cell types and their connectivity in human and other mammalian brains, in parallel with the BRAIN Initiative funding opportunity announcements (RFA-MH-22-290, RFA-MH-22-291, RFA-MH-22-292).
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2022 High Throughput Imaging Characterization of Brain Cell Types & Connectivity-Day 2, Part 3• VideoThe purpose of this NIH BRAIN Initiative workshop was to discuss unmet needs and emerging imaging approaches to characterizing brain cell types and their connectivity in human and other mammalian brains, in parallel with the BRAIN Initiative funding opportunity announcements (RFA-MH-22-290, RFA-MH-22-291, RFA-MH-22-292).
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2022 High Throughput Imaging Characterization of Brain Cell Types & Connectivity-Day 2, Part 4• VideoThe purpose of this NIH BRAIN Initiative workshop was to discuss unmet needs and emerging imaging approaches to characterizing brain cell types and their connectivity in human and other mammalian brains, in parallel with the BRAIN Initiative funding opportunity announcements (RFA-MH-22-290, RFA-MH-22-291, RFA-MH-22-292).
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2022 High Throughput Imaging Characterization of Brain Cell Types & Connectivity-Day 2, Part 5• VideoThe purpose of this NIH BRAIN Initiative workshop was to discuss unmet needs and emerging imaging approaches to characterizing brain cell types and their connectivity in human and other mammalian brains, in parallel with the BRAIN Initiative funding opportunity announcements (RFA-MH-22-290, RFA-MH-22-291, RFA-MH-22-292).
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2022 High Throughput Imaging Characterization of Brain Cell Types & Connectivity-Day 2, Part 6• VideoThe purpose of this NIH BRAIN Initiative workshop was to discuss unmet needs and emerging imaging approaches to characterizing brain cell types and their connectivity in human and other mammalian brains, in parallel with the BRAIN Initiative funding opportunity announcements (RFA-MH-22-290, RFA-MH-22-291, RFA-MH-22-292).
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2022 High Throughput Imaging Characterization of Brain Cell Types & Connectivity-Day 1, Part 2• VideoThe purpose of this NIH BRAIN Initiative workshop was to discuss unmet needs and emerging imaging approaches to characterizing brain cell types and their connectivity in human and other mammalian brains, in parallel with the BRAIN Initiative funding opportunity announcements (RFA-MH-22-290, RFA-MH-22-291, and RFA-MH-22-292).
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2022 High Throughput Imaging Characterization of Brain Cell Types & Connectivity-Day 1, Part 1• VideoThe purpose of this NIH BRAIN Initiative workshop was to discuss unmet needs and emerging imaging approaches to characterizing brain cell types and their connectivity in human and other mammalian brains, in parallel with the BRAIN Initiative funding opportunity announcements (RFA-MH-22-290, RFA-MH-22-291, and RFA-MH-22-292).
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Dr. Elisabeth Murray Honored With Mika Salpeter Lifetime Achievement Award• Institute UpdateDr. Elisabeth A. Murray has been honored with the 2022 Mika Salpeter Lifetime Achievement Award from the Society for Neuroscience recognizing her distinguished career in biomedical research and dedication to mentoring future leaders in neuroscience.
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Facebook Live: The Intersection of Suicide and Substance Use• VideoFor National Suicide Prevention Month, NIMH and NIDA co-hosted a Facebook Live on the link between suicide and substance use.
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A Clinical Pathway for Suicide Risk Screening in Adult Primary Care• Research HighlightAn NIMH-supported workgroup developed an evidence-based screening pathway to help primary care doctors identify adults at risk of suicide and bridge them to critical mental health services.
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Facebook Live: The Youth Mental Health Crisis• VideoNIMH Deputy Director Shelli Avenevoli, Ph.D., led a discussion on youth suicide, the effects of technology and the pandemic on the developing brain, and what the research says about supporting the mental health of current and future generations of youth.
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Facebook Live Event: The Menopause Transition and Depression• VideoNIMH experts discussed the signs, symptoms, treatments, and latest research on the menopause transition and depression.
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Get to Know Your Brain• VideoYour brain powers your thoughts, emotions, and actions, controlling every blink and heartbeat. Discover its parts and what each area does!
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What is informed consent?• VideoThis video explains what informed consent means in clinical trials participation.
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Understanding the Characteristics of Suicide in Young Children• Research HighlightResearchers supported by NIMH recently published a study describing the characteristics of suicide in young children and the factors that sometimes precede these tragic events, providing an avenue for future research and intervention.
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Severe Irritability• VideoNIMH is researching why some children have extreme irritability in response to reasonable requests and life events.
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Anna E. Ordóñez Named Director of NIMH’s Office of Clinical Research• Institute UpdateNIMH has selected Anna E. Ordóñez, M.D., M.A.S., as director of the Office of Clinical Research (OCR).
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The View of the NIMH Intramural Program From the Top: An Interview with Dr. Susan Amara• AudioDr. Peter Bandettini and Dr. Susan Amara discuss how advantages of the Intramural Research Program such as flexibility, diversity, and collaboration have led to major discoveries in mental health research.
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What are the risks and benefits of participating in clinical research?• VideoThis video will tell you about the risks and benefits of participating in clinical research.
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Guided Visualization: Dealing with Stress• VideoLearn about how stress affects the brain and practice a technique that can help you feel more relaxed and calmer when you are feeling stressed out.
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Getting to Know Your Brain: Dealing with Stress• VideoLearn about causes of stress and anxiety and how to cope, as well as how the brain works in teenagers and why this is such an important time of development.
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What are the different types of clinical research?• VideoThis video will tell you about the different types of clinical research.
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Study Identifies Risk Factors for Elevated Anxiety in Young Adults During COVID-19 Pandemic• Press ReleaseA new study has identified early risk factors that predicted heightened anxiety in young adults during the coronavirus pandemic.
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What is an MRI?• VideoThis video gives an example of what may happen during an MRI for research purposes.
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What is Clinical Research?• VideoThis video will give you a better understanding of what clinical research is.
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Gene Readouts Contribute To Distinctness of Mental Disorders• Press ReleaseA new study conducted by researchers at NIMH suggests that differences in the expression of gene transcripts – readouts copied from DNA that help maintain and build our cells – may hold the key to understanding how mental disorders with shared genetic risk factors result in different patterns of onset, symptoms, course of illness, and treatment responses.
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Nathan Lowry, Winner of the 2021 NIMH Three-Minute Talks Competition• VideoNathan Lowry discusses the relationship between a lifetime history of non-suicidal self-injury and suicide risk among an adult medical inpatient population.
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Lysianne Beynel, Winner of the 2021 NIMH Three-Minute Talks Competition• VideoLysianne Beynel discusses how to overcome the depth limitation of transcranial magnetic stimulation, or TMS, to modulate amygdala activity.
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Alyssa Luz-Ricca, Winner of the 2021 NIMH Three-Minute Talks Competition• VideoAlyssa Luz-Ricca explores abnormalities in reward processing to better understand the dysregulation of reward processing that occurs in certain psychological disorders.
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Alison Bashford, Winner of the 2021 NIMH Three-Minute Talks Competition• VideoAlison Bashford discusses how non-photic cues such as stress affect the circadian rhythm and therefore mental and physical health.
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Gabrielle Michel, Winner of the 2021 Three-Minute Talks Competition• VideoGabrielle Michel explores whether cardiovascular disease genetics predict aggression-related behaviors in people with schizophrenia.
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Malcolm Udeozor, Winner of the 2021 NIMH Three-Minute Talks Competition• VideoMalcolm Udeozor explores whether hand movements, like eye movements, are actually an inherent part of our memory that guide our recall of perceptual experiences.
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NIMH’s Carlos Zarate Jr., M.D., Elected to National Academy of Medicine• Institute UpdateCarlos Zarate Jr., M.D., chief of the Experimental Therapeutics and Pathophysiology Branch within the NIMH Intramural Research Program, has been elected to the National Academy of Medicine.
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Dr. Robert Savoy: fMRI Master Educator• Audio
Dr. Peter Bandettini interviews Dr. Robert Savoy from Harvard Medical School about his experiences training thousands worldwide in the use of Functional Brain Imaging.
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Study Shows Highly Reproducible Sex Differences in Aspects of Human Brain Anatomy• Press ReleaseA scientific analysis of more than 2,000 brain scans found evidence for highly reproducible sex differences in the volume of certain regions in the human brain.
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Outdoor Light Linked with Teens’ Sleep and Mental Health• Press ReleaseA large-scale study of U.S. teens shows associations between outdoor, artificial light at night and health outcomes.
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Zhen Ni: Transcranial Magnetic Stimulation: Cortical Anatomy and Clinical Neurophysiology• VideoDr. Zhen Ni, a research fellow at the National Institute of Neurological Disorders and Stroke, discusses how the response to transcranial magnetic stimulation (TMS) can be recorded, how spinal cord activity can be tested, how motor cortical stimulation with TMS is performed, and how stimulation outside of the motor cortex is achieved.
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Sarah H. Lisanby: Introduction to Transcranial Magnetic Stimulation• VideoDr. Sarah Lisanby, Director of the National Institute of Mental Health’s Noninvasive Neuromodulation Unit, describes the purpose of a series of training videos on transcranial magnetic stimulation.
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Sarah H. Lisanby: Transcranial Magnetic Stimulation Safety and Risk• VideoDr. Sarah Lisanby, Director of the NIMH Noninvasive Neuromodulation Unit, discusses the safety and risk of transcranial magnetic stimulation.
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Bruce Luber: TMS Parameters and Protocols• VideoDr. Bruce Luber of NIMH explores transcranial magnetic stimulation (TMS), its basic parameters, and research protocols studying its effects.
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Zhi-De Deng: Transcranial Magnetic Stimulation: Physics, Devices, and Modeling• VideoDr. Zhi-De Deng of NIMH explains the physics, devices, and modeling behind transcranial magnetic stimulation in neurostimulation research.
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Infant Temperament Predicts Personality More Than 20 Years Later• Press ReleaseResearchers investigating how temperament shapes adult life-course outcomes have found that behavioral inhibition in infancy predicts a reserved, introverted personality at age 26 and for some, a risk of internalizing psychopathology such as anxiety and depression.
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Introduction to the MRI Scanner• Video
This video describes what it’s like to have an MRI as part of your research study.
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Dr. Laura Lewis: Pushing fMRI into New Realms• Audio
Dr. Peter Bandettini sits down with Dr. Laura Lewis, an NIMH-supported researcher at Boston University, to discuss her groundbreaking work using fMRI to study the importance of sleep for the brain.