Update on Genes in the RDoC Matrix

As of May 2017, we removed references to specific genes from the “Genes” column in the RDoC matrix. We recognize the clear relevance of investigating genomic aspects of RDoC constructs and domains. However, the current state of the field emphasizes the need for robust evidence of association, generally resulting from adequately powered genome wide association studies, as opposed to candidate gene approaches. As we actively re-evaluate the specifics of information to be included in this column, the RDoC matrix will be updated accordingly.

If you are a researcher who is interested in incorporating genetic analyses in your RDoC study, please contact your NIMH Program Officer for further information.