Frustrative Nonreward RDoC ClassificationDomain: Negative Valence SystemsDescriptionReactions elicited in response to withdrawal/prevention of reward, i.e., by the inability to obtain positive rewards following repeated or sustained efforts.MoleculesDopamineGABAGlutamateSerotoninsteroidsVasopressinCircuitsAmygdalaHypothalamusLCOFCPAGparasympathetic systemSeptumstriatumBehaviorphysical and relational aggressionSelf-ReportFrustrative Nonreward Responsiveness SubscaleQuestionnaire of Daily FrustrationsParadigmsLab-TABPSAP