Extramural Programs and Contacts (Listed by Contact Name)

Ruben Alvarez

ruben.alvarez@nih.gov
301-443-4058

A3-NSNM1 / Neuromodulation and Neurostimulation Program

Division/Office: Division of Translational Research

Description: See A3-NSNM for program description.

D2-TDIT / Program in Informatics and Technology Development

Division/Office: Division of Data Science and Technology

Description: The Program in Informatics and Technology Development covers both technology development and informatics awards that are not covered in other programs. Examples of technologies include non-invasive devices, ultrasound, voltammetry, and other technologies that are not covered elsewhere in DST. Awards related to the Blueprint MedTech program are also part of this portfolio.

Paige Anderson

paige.anderson@nih.gov
301-827-6550

7T-SB1 / Assay Platform Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This SBIR & STTR Program supports research and development of pre-clinical assays and assay platforms related to basic brain and behavioral science, genetics, and drug discovery and development relevant to the mission of the NIMH. Such assays/platforms include high throughput tissue labeling technologies, multiplexed cell-based assays, and high throughput screening (HTS) technologies related to drug discovery or tool compound development, as well as associated (or novel) high throughput software technologies for analysis and data visualization.

Lizzy Ankudowich

lizzy.ankudowich@nih.gov
301-480-8187

A3-NSMN / Multimodal Neurotherapeutics Program

Division/Office: Division of Translational Research

Description: This program supports research that seeks to develop and refine multimodal or combination non-invasive neuromodulation therapies; identify and validate targets for novel interventions using such modalities; identify functional biomarkers associated with novel targets; and further elucidate brain-behavior relationships. The overall goal is to advance neurotherapeutics for major mental disorders and clinical dimensions of psychopathology (RDoC) through a ?non-siloed,? personalized medicine approach with an emphasis on the synergistic effects of combined approaches.

Alinne Barrera Loucheur

alinne.barrera@nih.gov
301-451-1451

85-TPAS1 / Adult Psychosocial Interventions Research Program

Division/Office: Division of Services and Intervention Research

Description: The psychosocial interventions research program supports research evaluating the effectiveness of psychosocial (psychotherapeutic and behavioral) therapeutic interventions, alone or in combination/sequence, on adultsa?? clinical course and functioning across domains (e.g., social/interpersonal, vocational functioning). Also included are research projects that relate to ethics in mental health, with support for empirical studies of ethical issues that accompany the conduct of mental disorders research involving human subjects. Topics relevant to this program include ethical issues regarding informed consent, assessing and mitigating risks in human subjects research, and dissemination of research findings.

85-TPAS2 / Adult Psychosocial Interventions Research Program

Division/Office: Division of Services and Intervention Research

Description: The psychosocial interventions research program supports research evaluating the effectiveness of psychosocial (psychotherapeutic and behavioral) therapeutic interventions, alone or in combination/sequence, on adultsa?? clinical course and functioning across domains (e.g., social/interpersonal, vocational functioning). In particular, research on interventions in perinatal periods will be included in this program.

Anita Bechtholt

anita.bechtholt@nih.gov
301-480-8368

BK-TK / Research Training and Career Development Program

Division/Office: Division of Translational Research

Description: The Division of Translational Research (DTR) Office of Research Training and Career Development supports research training at the predoctoral, postdoctoral, and early investigator level to ensure that highly trained research investigators will be available to address research questions pertinent to mental health and mental illness and thereby to reduce the burden of mental and behavioral disorders. Funding opportunities supported by DTR?s research training and career development offices include institutional (T32, R25) and individual training (F30, F31, F32, R36) and mentored career development (K01, K08, K23, K99/R00) programs.

BK-TKM / Training ? Biomarker and Intervention Development for Childhood-Onset Mental Disorders Research

Division/Office: Division of Translational Research

Description: The Division of Translational Research (DTR) Office of Research Training and Career Development supports research training at the predoctoral, postdoctoral, and early investigator level to ensure that highly trained research investigators will be available to address research questions pertinent to mental health and mental illness and thereby to reduce the burden of mental and behavioral disorders. Funding opportunities supported by DTR?s research training and career development offices include institutional (T32, R25) and individual training (F30, F31, F32, R36) and mentored career development (K01, K08, K23, K99/R00) programs.

BK-TKT / Training — Developmental Mechanisms and Trajectories of Psychopathology Research

Division/Office: Division of Translational Research

Description: The Division of Translational Research (DTR) Office of Research Training and Career Development supports research training at the predoctoral, postdoctoral, and early investigator level to ensure that highly trained research investigators will be available to address research questions pertinent to mental health and mental illness and thereby to reduce the burden of mental and behavioral disorders. Funding opportunities supported by DTR?s research training and career development offices include institutional (T32, R25) and individual training (F30, F31, F32, R36) and mentored career development (K01, K08, K23, K99/R00) programs.

Mesfin Bekalu

mesfin.bekalu@nih.gov
240-380-0341

9G-GMH2 / Digital Global Mental Health Program

Division/Office: Division of AIDS Research

Description: This program supports research on the development, testing, implementation, effectiveness, and costs of mobile technologies that are appropriate for low- and middle-income countries (LMICs). It supports highly-innovative mobile technology research for prevention, diagnosis, treatment, and management of mental disorders. This program is interested in research that tests generalizable principles or approaches in the use of technology in LMICs, encourages research on known challenges with uptake and sustainability of mobile technology-based approaches, and addresses ethical considerations associated with the use of mobile technologies for research and clinical purposes.

Yvonne Bennett

bennetty@mail.nih.gov
301-222-7094

D2-TDIM / Program in Imaging

Division/Office: Division of Data Science and Technology

Description: The Program in Imaging includes applications related to technology development in imaging. Examples of technologies include magnetic resonance imaging and positron emission tomography. This program includes computational approaches related to imaging. This portfolio also includes applications related to the Brain-Behavior Quantification and Synchronization program. The goal of that program is to develop quantitative measures of behavior and relevant environmental parameters.

Susan Borja

borjase@mail.nih.gov
301-443-1252

AD-TSC / Child Traumatic Stress Research Program

Division/Office: Division of Translational Research

Description: This program supports research on mental disorders in the context of traumatic stress as well as basic dimensions of functioning (e.g., fear circuitry, working memory, arousal, emotion regulation) relevant to traditionally defined or perceived posttraumatic psychopathology among children and adolescents. This includes studies that examine the developmental course of, periods of vulnerability or sensitivity for, or risk processes related to the onset, progression, recurrence, and recovery from traumatic stress disorders and their relevant components as well as preventive and treatment interventions.

AD-TSD / Dimensional Traumatic Stress Research Program

Division/Office: Division of Translational Research

Description: This program supports research to develop and refine measures of basic dimensions of functioning (e.g., fear circuitry, working memory, arousal, emotion regulation) relevant across traditionally defined or perceived posttraumatic psychopathology as well as interventions with dimensional therapeutic targets. Applications responsive to this program should apply emerging knowledge about genetics, brain circuitry and functioning, as well as behavior to aid in characterizing posttraumatic disorders. Further, applications may seek to validate approaches to assessing dysregulated/dysfunctional brain and behavioral functions, structures, connections, and processes that are predictive of symptoms and/or implicated in etiology or persistence of disorder or alternatively predictive of treatment responsiveness.

Linda Brady

lbrady@mail.nih.gov
301-443-3563

73-MCR / Drug Discovery and Clinical Therapeutics Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This program supports research aimed at designing and developing novel research tools (PET, SPECT, and fMRI imaging ligands); developing therapeutic agents for use in basic and clinical studies and for the treatment of mental disorders; and understand the clinical pharmacologic actions of therapeutic drugs and other treatments at the molecular and cellular level. Supported research includes studies of molecular pharmacology and structural chemistry of CNS receptors, transporters, ion channels, neuropeptides, and neuromodulators; investigations into drug-drug interactions; identification of pharmacological research tools and preclinical drug discovery. The program also supports the National Cooperative Drug Discovery Groups for the Treatment of Mood Disorders (NCDDG-MD). The NCDDG-MD supports public-private partnerships to accelerate the discovery of new mechanisms of action for therapeutics used for mood disorders; to increase the availability of pharmacologic research tools for basic and clinical research; and to facilitate the development and validation of models to evaluate novel therapeutics in mood disorders.

Andrew Breeden

andrew.breeden@nih.gov
301-451-3185

72-NBA / Affect, Social Behavior and Social Cognition Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Program supports integrative approaches to understanding the fundamental principles governing affect, social behavior, and social cognition in humans and animals. Topic areas include the fundamental mechanisms underlying emotions, mood, agonistic and affiliative behaviors, social communication and social cognition as well as investigations into their regulation and development. The program also supports work on fundamental mechanisms of social information processing.

Marcy Burstein

marcy.burstein@nih.gov
301-443-9699

85-TPCS1 / Child and Adolescent Psychosocial Interventions Research Program

Division/Office: Division of Services and Intervention Research

Description: The psychosocial interventions research program supports research evaluating the effectiveness of psychosocial (psychotherapeutic and behavioral) therapeutic interventions, alone or in combination/sequence, on children's and adolescents' mental and behavior disorders, including acute and longer-term therapeutic effects on clinical course and functioning across domains (e.g., school, family, peer functioning) with special focus on young children and early treatment.

Holly Campbell-Rosen

holly.campbell-rosen@nih.gov
301-827-9274

9G-GMH4 / Global Mental Health and Human Mobility Research Program

Division/Office: Division of AIDS Research

Description: This program supports research on the increasing mental health challenges faced by mobile populations at all stages of migration. Human mobility is broadly defined as human movement, as individuals or groups, including both long-term migration and/or short-term travel. Examples include livelihood mobility, displacement, household fluidity, rural to urban migrations, and involuntary mobility such as trafficking for sexual exploitation or forced labor. Mobile populations may experience a wide range of traumatic events that disrupt their lives, ability to earn income, safety and overall well-being. Mobile populations may experience a host of stressors and social and structural determinants (e.g., inadequate food and housing, stigma, discrimination, and poor linkage to healthcare services) that may negatively affect mental health and mental wellbeing at all stages of migration. This program seeks to develop assessment tools, preventives, interventions, and implementation strategies to better understand and improve mental health outcomes in people who are in transition or may have relocated.

Mark Chavez

mchavez1@mail.nih.gov
301-443-8942

A2-AIM / Eating Disorders Research Program

Division/Office: Division of Translational Research

Description: This program supports research on the etiology, core features, longitudinal course, and assessment of eating disorders. It also supports studies focusing on the elucidation of risk factors for the onset or recurrence of psychopathology. Intervention development studies grounded in findings from psychopathology are supported as the next step in the translation of basic research to effective treatments.

AK-TN / Research Training and Career Development Program

Division/Office: Division of Translational Research

Description: The Division of Translational Research (DTR) Office of Research Training and Career Development supports research training at the predoctoral, postdoctoral, and early investigator level to ensure that highly trained research investigators will be available to address research questions pertinent to mental health and mental illness and thereby to reduce the burden of mental and behavioral disorders. Funding opportunities supported by DTR?s research training and career development offices include institutional (T32, R25) and individual training (F30, F31, F32, R36) and mentored career development (K01, K08, K23, K99/R00) programs.

AK-TNAI1 / Training — Adult Psychopathology and Psychosocial Intervention Research

Division/Office: Division of Translational Research

Description: The Research Training and Career Development Program supports research training at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas relevant to the focus of the Division. This program supports training in Adult Psychopathology and Psychosocial Intervention Research.

AK-TNAI2 / Training — Adult Psychopathology and Psychosocial Intervention Research

Division/Office: Division of Translational Research

Description: See AK-TNAI1 for program description.

AK-TNGP1 / Training — Geriatrics Research

Division/Office: Division of Translational Research

Description: The Research Training and Career Development Program supports research training at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas relevant to the focus of the Division. This program supports training in Geriatrics Research.

AK-TNGP2 / Training — Geriatrics Research

Division/Office: Division of Translational Research

Description: See AK-TNGP1 for program description.

AK-TNNS1 / Training — Adult Pathophysiology and Biological Interventions Development Research

Division/Office: Division of Translational Research

Description: The Research Training and Career Development Program supports research training at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas relevant to the focus of the Division. This program supports training in adult pathophysiology and biological interventions development.

AK-TNNS2 / Training — Adult Pathophysiology and Biological Interventions Development Research

Division/Office: Division of Translational Research

Description: See AK-TNNS1 for program description.

AK-TNTS / Training — Traumatic Stress Disorders Research

Division/Office: Division of Translational Research

Description: The Research Training and Career Development Program supports research training at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas relevant to the focus of the Division. This program supports training in Traumatic Stress Disorders Research.

James Churchill

churchillj@mail.nih.gov
301-443-3621

DK-TE / Program in Training and Ethics

Division/Office: Division of Data Science and Technology

Description: This program includes all training activities managed by the Division of Data Science and Technology (DST). The portfolio also includes activities related to neuroethics.

Ashley Cornell

ashley.smith2@nih.gov
301-496-4406

AK-TNF / Individual Fellowship Opportunities Program

Division/Office: Division of Translational Research

Description: The Research Training and Career Development Program supports research fellowships at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas relevant to the focus of the Division. This program supports fellowships in adult pathophysiology and biological interventions development.

B4-TBX1 / Integrative Studies of Neurobehavioral Trajectories

Division/Office: Division of Translational Research

Description: See B4-TBX for program description.

BK-TKF / Individual Fellowship Opportunities Program

Division/Office: Division of Translational Research

Description: The Individual Fellowship Opportunities Program is designed to support research training at the pre-doctoral and post-doctoral career development levels. Research support is provided in areas relevant to the Division of Translational Research (DTR), such as psychosocial stress, child abuse and neglect, neurodevelopmental disorders, and affective regulatory disorders. The primary goal of the program is to provide promising applicants with the training necessary to become productive independent investigators in the area of developmental psychopathology. Training support is provided through the following programs: Individual Pre-doctoral and Post-doctoral Fellowships (F30, F31, F32) Dissertation Research Grants to Increase Diversity (R36)

Leonardo Cubillos

leonardo.cubillos@nih.gov
301-827-9095

9G-GMH / Center for Global Mental Health Research

Division/Office: Division of AIDS Research

Description: The Center for Global Mental Health Research provides scientific leadership and guidance to the planning, development, implementation and evaluation of global mental health research. The Center?s focus on global mental health reflects an understanding of how the rapid movements of populations, global economic relationships, and communication technologies have created more permeable borders and new forms of interconnectedness among nations and people. The office supports research that: (1) promotes strategies to increase attention and resources devoted to mental health and demand for evidence-based mental health care; (2) is basic or applied science on the mental health of individuals living in low-resource setting worldwide, with special attention to those living in low- and middle-income countries; (3) supports the development and maintenance of a diverse, multidisciplinary global mental health research workforce; (4) supports capacity-building, research infrastructure development, and research mentoring to develop a multidisciplinary mental health research workforce in low- and middle-income countries; and (5) examines disparities in the incidence, prevalence, and course of mental disorders; access to evidence-based care; and the quality, effectiveness, and outcomes of mental health care across diverse populations using a global perspective.

9G-GMH1 / Global Mental Health Effectiveness Research Program

Division/Office: Division of AIDS Research

Description: The goal of this program is to improve global mental health outcomes through novel interventions or service models that improve clinical benefit, practice and scalability. This program supports research that uses an experimental therapeutics approach to developing and testing interventions to prevent and treat mental illnesses in diverse populations living in low-and middle-income countries (LMICs). Areas of Emphasis, Hybrid effectiveness-implementation, studies that develop, test, and optimize efficacy or effectiveness of preventive and treatment interventions for mental illnesses among children, youth, and adults living in LMICs, studies that investigate the effectiveness and cost-effectiveness, effectiveness research to develop and test the integration of mental health interventions into existing care for other non-communicable diseases and/or for HIV.

Beshaun Davis

beshaun.davis@nih.gov
301-827-5098

15-DRMP / Mental Health of Minoritized Populations Research Program

Division/Office: Office of the Director

Description: This program supports research aimed at reducing mental health disparities and enhancing scientific knowledge about the mental health of minoritized and underserved populations. Areas of interest include variations in course, severity, risk and resilience, prevalence and incidence of mental illnesses and access, utilization, quality, and implementation of evidence-based mental health services across diverse populations, research focusing on the critical roles of context and socioeconomic status on the development of neuropsychiatric disorders, and the importance of community engagement to inform mental health research.

15-DRSD / Social Determinants of Mental Health Disparities Research Program

Division/Office: Office of the Director

Description: This program supports research aimed at examining and increasing scientific knowledge relating to the social determinants of mental health disparities and ways to reduce their impact on the mental health of minoritized and marginalized populations in the United States. Areas of interest include research on risk and protective factors, including those beyond the individual level, and an understanding of mechanisms underlying the impact of social drivers of disparate mental health outcomes to inform novel interventions, including, but not limited to, multi-level systemic interventions that can reduce or eliminate disparities

Jamie Driscoll

jd366b@nih.gov
301-443-5288

73-MCT / Signal Transduction Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This program supports fundamental research on the molecular and cellular substrates of neuronal signaling, the factors that influence the signaling process, and the mechanisms that underlie changes in signaling strength. Research supported by this program include studies of neurotransmitters, signaling cascades, and second messengers systems; studies of compartmentalization, targeting, and trafficking of signaling molecules; studies of pre- and post-synaptic proteins, neurotransmitter transporters, ion channels, and ion pumps; and studies of synaptic growth and synaptic plasticity.

7K-TGDG1 / Training — Developmental and Genomic Neuroscience Research

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: See 7K-TGDG for program description.

7K-TGMC1 / Training — Molecular, Cellular, and Genomic Neuroscience Research

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: See 7K-TGMC for program description.

Jaclyn Durkin

jaclyn.durkin@nih.gov
301-594-8472

7T-SB / Technologies Enhancing the Understanding of CNS Structure, Function and Behavior

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This program supports research and development of tools related to basic brain and behavioral science relevant to the mission of the NIMH. Such tools include: software (such as informatics tools for analyzing data, and approaches for making better sense and use of data about behavior and the brain); hardware (such as the development of instrumentation or devices); and biochemical tools (such as molecular imaging agents or genetic approaches to label neural circuits or modify circuit functions).

Jovier Evans

je180t@nih.gov
301-443-1369

A4-GP / Geriatrics and Aging Processes Research Branch

Division/Office: Division of Translational Research

Description: The Geriatrics and Aging Processes Research Branch supports programs of research, research mid-career development, and resource development in the etiology, pathophysiology and course of mental disorders of late life, the relationships between aging and mental disorders, the treatment and recovery of persons with aging-related disorders, and the prevention of these disorders and their consequences. In addition to studies focused on older adults and their particular mental health issues and needs, the Branch supports neurodevelopmental investigations of potential risk and resilience factors pertinent to mental disorders and longer-range trajectories of change that may involve examining individuals during earlier phases of the life span, as well. The program encourages collaborative multidisciplinary research programs using the tools of neuroscience, cognitive and affective sciences, and social and behavioral sciences to facilitate the translation of basic science and preclinical research to clinical research. Studies may involve use of brain imaging, genetics and genomics, molecular biology and other evolving neuroscientific methods to investigate factors related to neuropsychiatric disorders of aging, the interaction of these disorders with the processes of aging and neurodevelopment/neurodegeneration, and their assessment and treatment. Disorders of interest include: Mood, anxiety, and personality disorders; psychotic disorders and schizophrenia; psychiatric syndromes and behavioral disturbances in Alzheimer's disease and related dementias; suicide; and neuroregulatory and homeostatic disorders associated with irregularities of sleep, eating, and the menstrual cycle.

A4-GPB / Behavioral Science of Mental Disorders and Aging Program

Division/Office: Division of Translational Research

Description: This program supports studies of behavioral and psychosocial factors and processes that may influence the risk, presentation, course, and outcome of mental disorders in late life or in relation to the aging process. There is particular interest in supporting research consistent with NIMH?s emphasis on taking a dimensional and trans-diagnostic approach in studies of psychopathology, as articulated in the Institute?s Research Domains Criteria (RDoC) project. Relevant research typically uses the theories and tools of the social and behavioral sciences, clinical geropsychology, and cognitive and affective science to assess key psychosocial variables, but also may involve neurobiological components so as to examine these constructs across multiple levels of analysis. The integration into the research of indices of the aging process, including concepts and measures drawn from psychological and social theories of adult development and aging, is highly encouraged. Studies may include middle-aged or younger patients as well as older adults when there is a major focus on questions pertaining to the aging process, such as in research on the trajectories of mental disorders with aging.

A4-GPS / Psychosocial Intervention and Aging Program

Division/Office: Division of Translational Research

Description: This program supports experimental and observational studies aimed at developing and testing behavioral and psychosocial interventions for the treatment, prevention, or rehabilitation of the mental disorders of late life. There is particular interest in supporting studies consistent with NIMH?s emphases on clinical innovation and an experimental therapeutics model for clinical trial investigations. Depending on the intervention questions being posed, approaches for use in acute, continuation, or maintenance phases of treatment might be evaluated. The program includes studies of strategies for long-term maintenance of clinical benefits, relapse prevention and enhancement of function/reduction of disability as well as for acute symptom alleviation. Research on the real-world effectiveness as well as efficacy of interventions is supported. Studies may include middle-aged or younger patients as well as older adults when there is a major focus on questions pertaining to the aging process. This program also supports studies of the correlates, predictors, modifiers, and mediators of variability in older adults? response to behavioral and psychosocial interventions so as to advance understanding of the interventions? mechanisms of action and to promote personalization of care.

A4-GPX / Pharmacologic and Somatic Intervention and Aging Program

Division/Office: Division of Translational Research

Description: This program supports experimental and observational studies aimed at developing and testing pharmacologic, neuromodulatory, and other somatic interventions for treating, preventing or promoting recovery from the mental disorders of late life. There is particular interest in supporting studies consistent with NIMH?s emphases on clinical innovation and an experimental therapeutics model for clinical trial investigations. Depending on the intervention questions being posed, approaches for use in acute, continuation, or maintenance phases of treatment might be evaluated. The program includes studies of strategies for long-term maintenance of clinical benefits, relapse prevention and enhancement of function/reduction of disability as well as for acute symptom alleviation. Research on the real-world effectiveness as well as efficacy of interventions is supported. Studies may include middle-aged or younger patients as well as older adults when there is a major focus on questions pertaining to the aging process. This program also supports studies of the correlates, predictors, modifiers, and mediators of the variability in older adults? response to pharmacologic and somatic interventions so as to advance understanding of the interventions? mechanisms of action and to promote personalization of care.

Greg Farber

farberg@mail.nih.gov
301-435-0778

D1-IND / Cross-Cutting Research Program in Infrastructure, Informatics and Technology Development

Division/Office: Division of Data Science and Technology

Description: The Program in Infrastructure, informatics, and Technology Development is responsible for NIMH efforts related to informatics and technology development as well as infrastructure activities at NIMH infrastructure activities. This research program is focused on oversight activities for the Division.

Fernando Fernandez

fernando.fernandez@nih.gov
301-793-6566

72-NBI / Integrative Behavioral Neuroscience program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The program supports integrative systems-level studies using innovative approaches that connect micro, meso and macro scale neural signals with a goal to understand how neural circuits encode and represent complex behaviors important for mental health. Of special interest are studies that probe the neural circuits that subserve reward and motivation, cognitive function, learning and memory, and social/affective neuroscience. This program seeks to accelerate research proposing causal experimental designs, cutting edge behavioral and neurobiological approaches, and multiple levels of analysis with the goal to understand how neural circuits represent, encode and compute complex behaviors.

Michele Ferrante

michele.ferrante@nih.gov
301-793-2634

A2-AIC / Translational Digital and Computational Psychiatry Program

Division/Office: Division of Translational Research

Description: The overarching goal of this program is to foster innovative computational approaches to identify and validate novel mechanisms, biomarkers, and treatment targets relevant to the prevention and treatment of psychiatric disorders. The program supports research projects that use advanced computational methods with behavioral, biological, and/or clinical data to decipher complex mechanisms involved in mental disorders and to conduct initial tests of novel tools to predict risk, clinical trajectories, and treatment response. Toward these goals, the program also supports translational research focused on novel computational approaches to dissecting the heterogeneity of mental disorders and the use of computational models for validating RDoC constructs in clinical populations. The program encourages the development and testing of novel tools that modulate mental health treatment targets or enhance the precision of mental health assessments through the use of passive and active sensing devices. It also focuses on research and development of novel computational methods used in the diagnosis, treatment, and prevention of various forms of psychopathology. Consistent with the focus of the branch on adult psychopathology applications assigned to this program address anxiety and mood disorders, personality pathology, and psychosis in adults 18 years of age and older. Computational methods in this program typically involve research translating basic science knowledge to discover phenotypic characterization, etiology, pathophysiology, trajectory, risk and resilience, and develop efficacious interventions for mental health conditions. These translational research studies include software-based tools being tested for early-stage efficacy, typically phase I/II Clinical Trials.

Michael Freed

michael.freed@nih.gov
301-443-3747

82-SE / Services Research and Clinical Epidemiology Branch

Division/Office: Division of Services and Intervention Research

Description: This Branch plans, supports and administers programs of research, research training, and research infrastructure development, across the lifespan, on all mental health services research issues, including but not limited to: (1) Services organization, delivery (process and receipt of care), and related health economics at the individual, clinical, program, community and systems levels in specialty mental health, general health, and other delivery settings (such as the workplace); (2) Interventions to improve the quality and outcomes of care, including diagnostic, treatment, preventive, and rehabilitation services. (3) Enhanced capacity for conducting services research; (4) The clinical epidemiology of mental disorders across all clinical and service settings; (5) The dissemination and implementation of evidence-based interventions into service settings.

82-SEDR / Dissemination and Implementation Research Program

Division/Office: Division of Services and Intervention Research

Description: This program includes studies that will contribute to the development of a sound knowledge base on the effective transmission of mental health information to multiple stakeholders and of the process by which efficacious interventions can be adopted within clinical settings. Research on dissemination will address how information about mental health care interventions is created, packaged, transmitted, and interpreted among a variety of important stakeholder groups.

82-SEDRA / Dissemination and Implementation Research Program

Division/Office: Division of Services and Intervention Research

Description: This program includes studies in general medical settings that will contribute to the development of a sound knowledge base on the effective transmission of mental health information to multiple stakeholders and of the process by which efficacious interventions can be adopted within clinical settings. Research on dissemination will address how information about mental health care interventions is created, packaged, transmitted, and interpreted among a variety of important stakeholder groups.

82-SEDRJ / Dissemination and Implementation Research Program

Division/Office: Division of Services and Intervention Research

Description: This program includes studies in specialty mental health and community settings that will contribute to the development of a sound knowledge base on the effective transmission of mental health information to multiple stakeholders and of the process by which efficacious interventions can be adopted within clinical settings. Research on dissemination will address how information about mental health care interventions is created, packaged, transmitted, and interpreted among a variety of important stakeholder groups.

82-SEDRP / Dissemination and Implementation Research Program

Division/Office: Division of Services and Intervention Research

Description: This program includes studies involving child and adolescent populations and settings that will contribute to the development of a sound knowledge base on the effective transmission of mental health information to multiple stakeholders and of the process by which efficacious interventions can be adopted within clinical settings. Research on dissemination will address how information about mental health care interventions is created, packaged, transmitted, and interpreted among a variety of important stakeholder groups.

82-SEDRR / Dissemination and Implementation Research Program

Division/Office: Division of Services and Intervention Research

Description: This program includes studies of research methods development and economic analyses that will contribute to the development of a sound knowledge base on the effective transmission of mental health information to multiple stakeholders and of the process by which efficacious interventions can be adopted within clinical settings. Research on dissemination will address how information about mental health care interventions is created, packaged, transmitted, and interpreted among a variety of important stakeholder groups.

Stacia Friedman-Hill

friedmans@mail.nih.gov
301-443-8458

B4-TBC / Risk and Early Onset of Psychosis Spectrum Disorders

Division/Office: Division of Translational Research

Description: This program supports research on childhood and adolescent psychosis and thought disorders, including genetic phenotypes known to confer risk and prodromal symptomatology. Prospective studies that illuminate mechanisms and trajectories of psychopathology in model animals or humans are welcomed. Of interest are studies that examine the developmental course, periods of vulnerability or sensitivity, or risk processes related to the onset, progression, recurrence, and remission of psychopathology and its relevant components. NIMH strongly encourages use of the Research Domain Criteria (RDoC) research framework to identify circuits and functional domains that are key to the development of psychosis and can serve as predictive biomarkers. Of particular interest are studies that link brain development with behavioral development, studies that identify biomarkers for disease progression, and studies that test integrative models incorporating biological, behavioral, and environmental/experiential factors in the development of psychopathology.

B4-TBM / Mood Lability and Affective Dysregulation Program

Division/Office: Division of Translational Research

Description: This program supports research on the neurodevelopmental trajectories and mechanisms of mental illness associated with affect regulation, emotion, and stress reactivity, including mood lability, bipolar disorder, borderline personality disorder, and related phenotypes and prodromal symptomatology. Of interest are studies that examine the developmental course of, periods of vulnerability or sensitivity for, or risk processes related to the onset, progression, recurrence, and remission of these disorders and their relevant components. Of particular interest are studies that link brain development with behavioral development; studies that identify biomarkers for disease progression; studies that identify sensitive periods for typical and atypical developmental trajectories; studies that elucidate biomarkers and mechanisms of disease progression; studies delineating mechanisms of sex and gender differences in the development of these phenotypes; and studies that test integrative models incorporating multiple levels of analysis (biological, behavioral and environmental) across multiple RDoC constructs.

Marjorie Garvey

garveym@mail.nih.gov
301-443-4491

B2-MBB / Novel Strategies for Treatment of Developmental Psychopathology

Division/Office: Division of Translational Research

Description: The overarching goal of this program is to support research using an experimental medicine approach to foster development of novel strategies for assessment, treatment, and recovery from mental illnesses in children and adolescents. This program supports the development of novel cognitive, behavioral, and other psychosocial interventions. This program also supports studies that administer an evidence-based intervention to investigate the mechanisms of treatment effect and/or to identify biomarkers of treatment response.

B2-MBT / Novel Strategies for Early and Preventive Interventions

Division/Office: Division of Translational Research

Description: This program supports the development of novel behavioral, cognitive, and other psychosocial approaches to ameliorate or prevent the emergence of mental disorders in very young children. The program also supports interventions targeting the prodromal or preclinical stages of serious mental illness in children and adolescents, with the aim of altering the trajectory of developmental psychopathology and optimizing outcomes. The overarching goal is to facilitate the translation of emerging basic or clinical science findings into novel interventions. Thus, interventions that target recently-identified mechanisms underlying mental disorders in children and adolescents, and/or factors that confer risk for these disorders, are of particular interest. Highly innovative approaches to intervene on an established mechanism are also of interest, if the novel approach has the potential to significantly improve functional outcomes.

Lisa Gilotty

gilottyl@mail.nih.gov
301-443-3825

B2-MB / Biomarker and Intervention Development for Child Onset Mental Disorders Branch

Division/Office: Division of Translational Research

Description: This branch supports research leading to the development of novel, mechanism-based treatments and preventive interventions for childhood-onset mental disorders. The programs within this branch support research to develop novel cognitive, behavioral, psychosocial, pharmacological, and device-based interventions. The branch also supports the identification of reliable and valid biomarkers useful for stratification of research participants in clinical trials or for use as objective predictors or indicators of treatment response (surrogate endpoints). The development of novel technologies, analytic strategies, and other resources for the characterization of individuals for the purposes of stratification into clinical trials, personalizing treatment, and monitoring response to treatment are of interest, particularly approaches that quantify cognitive, emotional, sensorimotor and biobehavioral processes that are often shared across diagnostic categories. The Autism Research Program is also administered within this branch, and supports a wide range of research on the characterization, pathophysiology, treatment, and outcomes of individuals with autism spectrum disorders and related neurodevelopmental disorders.

B2-MBA / Research Program on Autism Spectrum Disorders

Division/Office: Division of Translational Research

Description: This program supports research designed to elucidate the characterization, pathophysiology, treatment and outcomes of autism and related disorders. Of particular interest are studies that will lead to enhanced phenotyping, a better understanding of mechanisms and underlying neurobiology, validated measures for use as stratification tools or to assess outcomes in response to treatment, and novel treatments and intervention strategies.

Christopher Gordon

cgordon1@mail.nih.gov
240-627-3867

9A-ASG / HIV Intervention and Implementation Science Branch

Division/Office: Division of AIDS Research

Description: This Branch supports research to understand and prevent adverse health outcomes among people at highest risk of acquiring HIV as well as people living with HIV/AIDS. The Branch also encourages the translation and adoption of effective interventions into community-based clinical, treatment, and other settings. Priorities in this program include the development and testing of theory-driven interventions to improve linkage to HIV prevention and care, adherence to prevention and treatment therapies, and promotion of other biobehavioral prevention interventions to reduce HIV acquisition and transmission, promote healthy lifestyle choices, and reduce high-risk behaviors.

9A-ASGC / HIV Prevention and Treatment Implementation Science Program

Division/Office: Division of AIDS Research

Description: This program encourages research to enhance the uptake, effectiveness and efficiency of evidence-based interventions, and to inform and enhance the effectiveness and efficiency of interventions currently available in the continuum of HIV prevention, HIV testing, and HIV care, to maximize community impact. Significant progress is needed to transfer interventions from one setting or population to another, and to make informed choices between competing interventions to maximize their effect in target populations. This gap between research and implementation is impeding success in prevention, care, and treatment programs in the number of people reached and effects on health outcomes. Advances are urgently needed to reduce these unknowns and increase the public health impact of HIV/AIDS prevention, treatment, and care services.

Meg Grabb

mgrabb@mail.nih.gov
301-443-3563

7T-ST / Drug Discovery and Development Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This SBIR & STTR program supports development of novel pharmacologic agents for the treatment of mental disorders, from early preclinical development through first in human trials.

AT-BI / Small Business Innovation Research and Small Business Technology Transfer Program

Division/Office: Division of Translational Research

Description: The Small Business Innovation Research (SBIR) Program supports research and development by small businesses of innovative technologies that have the potential to succeed commercially or to provide significant societal benefits. The Small Business Technology Transfer (STTR) Program has the same objectives but requires academic research involvement.

B2-MBP / Novel Pharmacological and Device-based Intervention Program for Pediatrics

Division/Office: Division of Translational Research

Description: This program supports research leading to the development of novel pharmacologic and device-based treatments for childhood-onset mental disorders. Of interest are research to evaluate the molecular and circuit-base targets of these interventions, to optimize dosing, to evaluate safety and tolerance, and to evaluate the association between target engagement and the effect on symptoms or functional domains. Also of interest are the development of reliable and stable biomarkers of pediatric approved drug and device-based interventions to provide missing information highly needed in the field on the central targets and mechanisms; indicators of treatment response or drug safety; and to biologically identify subjects that would best respond to the intervention for stratification purposes.

BT-BU / Small Business Innovation Research and Small Business Technology Transfer Program

Division/Office: Division of Translational Research

Description: The Small Business Innovation Research (SBIR) Program supports research and development by small businesses of innovative technologies that have the potential to succeed commercially or provide significant societal benefits. The Small Business Technology Transfer (STTR)Program has the same objectives, but requires academic research involvement.

Gregory Greenwood

gregory.greenwood@nih.gov
240-669-5532

9A-ASPT / HIV Testing and Social Determinants Program

Division/Office: Division of AIDS Research

Description: This program specifically encourages studies to develop and test novel approaches to increase HIV testing and identification of people living with HIV for active linkage to care, or high-incidence populations for active linkage to ongoing prevention services. This program also encourages research to understand social determinants (e.g., HIV-related intersectional stigma and discrimination) and to intervene on the socioecological factors that can facilitate or impede optimal access to and use of effective HIV prevention strategies (e.g., HIV testing and HIV Care Continuum). Socioecological factors of interest include, but are not limited to societal policies, structural and economic influences, environmental and community settings, sexual and social networks, and individual mental health functioning. Studies that investigate the optimal combination of interventions, including multi-level approaches to ensure the most effective uptake and effectiveness of HIV prevention and testing are encouraged as well. Research may be conducted in U.S. domestic settings or in international settings that have high HIV incidence or prevalence, with an emphasis on approaches likely to have broad impact.

Adam Haim

haima@mail.nih.gov
301-435-3593

85-TP / Treatment and Preventive Interventions Research Branch

Division/Office: Division of Services and Intervention Research

Description: The Branch plans, supports, and administers programs of research, research training, and research infrastructure development to evaluate the therapeutic benefits of mental health preventive, treatment, and rehabilitative interventions alone and/or in combination, for children, adolescents, and adults. The programmatic focus is broad and inclusive with respect to the heterogeneity of individual characteristics and patient needs, the severity and chronicity of disorders, and the variety of community and institutional settings where interventions are provided. In funding decisions, emphasis is placed on the potential clinical impact of the research activities and on the implications of the research findings for improving community practice and health outcomes. Types of interventions include the full range of behavioral, psychotherapeutic, pharmacologic, and non pharmacologic somatic or alternative interventions, as well as rehabilitation or other adjunctive services, e.g., integrated approaches to chronic mental illness. Outcome measures extend beyond symptom reduction to include short- and long-term assessment of functioning. Other areas of emphasis include the identification of moderators and mediators of intervention effects, and their use to develop and test more targeted and personalized interventions, evaluation of the combined or sequential use of interventions of similar or different modalities (e.g., to extend efficacy among refractory subgroups), determination of the optimal length of treatment, establishment of the utility of continuation or maintenance treatment for prevention of relapse and recurrence, and the evaluation of the long-term impact of efficacious interventions on symptoms and functioning.

8T-SB / Small Business Innovation Research Program and Small Business Technology Transfer Program

Division/Office: Division of Services and Intervention Research

Description: The Small Business Innovation Research (SBIR) Program supports research and development by small businesses of innovative technologies that have the potential to succeed commercially or provide significant societal benefits. The Small Business Technology Transfer (STTR) Program has the same objectives but requires academic research involvement.

Brittany Haynes

brittany.haynes@nih.gov
301-496-2767

15-DRWD / Research Workforce Diversity and Equity Program

Division/Office: Office of the Director

Description: The ODWD Workforce Diversity and Equity Program employs a variety of approaches to enhance the development and maintenance of a diverse, multidisciplinary mental health research workforce within the United States. The program comprises training, capacity building, outreach, mentorship, and education programs ranging from high school through the early-stage faculty level to support the career development of those conducting mental health research in scientific areas relevant to the mission of the NIMH, and inclusive excellence in the mental health research workforce.

15-SGD / Minority Mental Health Research Program

Division/Office: Office of the Director

Description: This research program supports research aimed at reducing mental health disparities and increasing attention to women's mental health, and the mental health needs of minority and underserved populations. Areas of interest include variations in incidence, prevalence, and course of mental disorders and access to care across diverse populations, research focusing on the critical roles of context and socioeconomic status on the development of neuropsychiatric disorders, and strategies for measuring mental health disparities.

Lauren Hill

hillla@mail.nih.gov
301-443-2638

15-DR / Office for Disparities Research and Workforce Diversity

Division/Office: Office of the Director

Description: The Office for Disparities and Workforce Diversity (ODWD) coordinates two significant priorities at NIMH, research on mental health disparities and mental health equity in the United States and generating and sustaining a diverse, inclusive, and highly skilled mental health research workforce. ODWD works collaboratively with NIMH offices and divisions; NIH Institutes, Centers, and Offices, and others by providing scientific leadership and guidance to the planning, development, and implementation of biomedical and behavioral research relevant to mental health disparities and the mental health of minoritized populations in the United States. The office supports research that investigates strategies to reduce mental health disparities, improve women's mental health and the mental health of minoritized and underserved populations, the mental health of people living with disabilities, sexual and gender minority, and underserved rural populations. The ODWD Workforce Diversity and Equity Program employs a variety of approaches to support the development and maintenance of a diverse, multidisciplinary mental health research workforce within the United States through research training, capacity building, outreach, mentorship, and education programs ranging from high school through the early-stage faculty level.

Mi Hillefors

mi.hillefors@nih.gov
301-443-2738

A3-NST / Neuroinflammation and Clinical Therapeutics Research Program

Division/Office: Division of Translational Research

Description: This program supports research seeking to develop a mechanistic understanding of how interactions between the immune system and the central nervous system contribute to psychopathology in adults (ages 18+). Experimental approaches may include genetic analysis, inflammatory pathways, animal models, neuroimaging, and electrophysiology.

Jennifer Humensky

jennifer.humensky@nih.gov
301-480-1265

82-SEEC / Financing and Managed Care Research Program

Division/Office: Division of Services and Intervention Research

Description: This program supports research on economic factors affecting the delivery of mental health services including the economic burden of mental illness; financing and reimbursement of public and private mental health services; impact of various forms of managed care and physician payment methods on the cost of mental health care; pharmaco-economics; evaluation of the impact of insurance coverage including mandated coverage and mental health insurance parity on access, cost, and quality; cost-benefit, cost-effectiveness and cost-utility analysis of mental health service interventions; and economic analysis of practice patterns of different mental health providers. The goal of the program is to expand understanding of the role of economic factors in the delivery and use of mental health services and assist in the development of improved mental health financing methods promoting high quality, cost-effective care for people suffering from mental disorders.

Sofiya Hupalo

sofiya.hupalo@nih.gov
301-827-3752

73-MCP / Integrative Systems Pharmacology

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This program supports interdisciplinary neuroscience research aimed at identifying molecular and cellular mechanisms underlying the behavioral actions of psychoactive drugs. The program focuses on identifying novel targets (genes, molecules) for therapeutic intervention in mental disorders using appropriate models and measures relevant to neuropsychiatric disorders.

Daniel Janes

janesde@mail.nih.gov
301-594-1544

D2-TDIN / Program in Informatics

Division/Office: Division of Data Science and Technology

Description: The Program in Informatics includes applications related to informatics. Specific topical areas in the portfolio include new statistical methods, broad informatics activities, software development, data archives, and data standards. Computational approaches related to imaging techniques are excluded from this portfolio.

Jeymohan Joseph

jjeymoha@mail.nih.gov
240-627-3869

9A-ASN / HIV Neuropathogenesis, Genetics, and Therapeutics Branch

Division/Office: Division of AIDS Research

Description: This Branch supports an integrated program of studies to elucidate the pathophysiology and genetic factors contributing to HIV-associated neurologic and neurocognitive dysfunction. The Branch also supports the development of novel therapeutic strategies derived from HIV neuropathogenesis research to mitigate central nervous system complications of HIV infection.

9A-ASNE / Eradication HIV-1 from CNS/Myeloid Reservoirs Program

Division/Office: Division of AIDS Research

Description: This program supports innovative research in five areas: (1) basic research to identify and characterize persistent/latent HIV-1 in cells derived from the central nervous system (CNS), such as macrophages, microglia, and/or astrocytes, in the setting of suppressive anti-retroviral therapy; (2) basic research to determine the mechanisms involved in the temporal establishment, maintenance, and resurgence of persistent/latent HIV-1 in the CNS, in relationship to the timing of antiretroviral therapy; (3) development of physiologically relevant animal models and CNS-based cellular assays that recapitulate HIV-1 persistence and latency in the presence of effective highly active antiretroviral therapy (HAART); (4) feasibility assessments of current and emerging eradication approaches to have successfully reactivated persistent HIV from CNS-derived cells such as macrophages, microglia and astrocytes; and (5) assessment of CNS toxicity and adverse impact of current and emerging eradication strategies.

9A-ASNG / Viral/Host Genetics Program

Division/Office: Division of AIDS Research

Description: This program supports basic and clinical research to determine the viral and host genetic factors regulating the development of neurologic and neuropsychiatric complications caused by HIV in the developed and developing world. The program encourages use of state-of-the-art genetic approaches (e.g., transcriptomics, phenomics, epigenomics, whole genome association studies, next generation sequencing, exome sequencing, and system biology) to identify and validate viral and host genetic factors that influence the pathophysiology of HIV-associated neurocognitive disorders (HAND).

Susannah Kamath

sa131w@nih.gov
240-627-3861

9A-ASF / Fellowship Program

Division/Office: Division of AIDS Research

Description: Supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in areas relevant to the focus of the Division. The program includes training both in the basic neuroscience of HIV infections, as well as the behavioral science research agenda.

9A-ASH / Health Disparities Program

Division/Office: Division of AIDS Research

Description: Health Disparities program, which promotes multidisciplinary research and research training on mental health issues related to HIV/AIDS amoung underrepresented diverse racial/ethnic communities in order to reduce the disproportionate burden ofthe HIV/AIDS epidemic on these populations. The major focus of the disparities program is to: (1) enhance diversity in the AIDS mental health research workforce through research capacity building efforts; and (2) support partnerships through collaborative and integrated programs for academic-research-community linkages and for community-based participatory training and research. These two inter-related programs incorporate experiences in didactics (and other relevant curricula and academic enrichment) and research that encourage translational and interdisciplinary approaches.

9A-ASPA / Adolescent and Young Adult HIV Research Program

Division/Office: Division of AIDS Research

Description: This program supports research to advance the understanding of how best to prevent the acquisition of HIV among adolescents and young adults. The program also supports research to improve the health outcomes of adolescents and young adults who are living with HIV. Research that takes into account the unique developmental considerations across these time periods as well as the multiple levels of influence on adolescents and young adults is strongly encouraged.

9A-AST / Training Program

Division/Office: Division of AIDS Research

Description: The Research Training and Career Development Program supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in areas relevant to the focus of the Division. This includes research training and early career development in: developing and disseminating effective preventive interventions in domestic and international settings. The primary goal of the training program is to ensure that sufficient numbers of highly trained independent investigators will be available to address the complexities of mental health research in HIVAIDS. The AIDS training programs encourages interdisciplinary and translational research approaches.

9G-GMHT / Global Mental Health Research Training Program

Division/Office: Division of AIDS Research

Description: The Global Mental Health Research Training Program supports research training at the high school, pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to global mental health, including research training, research education, research capacity building, and research infrastructure development.

Douglas Kim

douglas.kim@nih.gov
301-827-6463

D2-TDND / Program in Neurotechnology, Dissemination, and Diversity

Division/Office: Division of Data Science and Technology

Description: The Program in Neurotechnology, Dissemination, and Diversity supports development of new technologies for basic and applied neuroscience research. This includes support for molecular, genetic, and novel imaging tools and methods for study of brain structure and function at the subcellular, cellular, and circuit levels. The program has a special emphasis on making reagents and technologies available to the research community. Some of those dissemination activities involve minority serving institutions and Institutional Development Award (IDeA) eligible institutions.

Eunyoung Kim

eunyoung.kim@nih.gov
301-408-8107

D2-TDCC / Program in Technologies to Understand Cells and Circuits

Division/Office: Division of Data Science and Technology

Description: The Program in Technologies to Understand Cells and Circuits supports the development of novel tools and technologies for basic and applied research for studying brain mechanisms and behaviors at the cell and circuit level. This includes the development of both technologies and hardware. Examples include: The development of novel technologies or innovative methods for imaging, mapping, accessing, and manipulating specific brain cell types via molecular or genetic based approaches, the development of new pipelines for optical and circuit data collection and analysis, and the improvement of existing technologies to increase specificity or temporal and spatial resolution for in vivo measurements or to access cells and circuits in multiple species.

Erin King

erin.king2@nih.gov
301-451-4794

B4-TBD1 / Depression and Suicide Related Behaviors Program

Division/Office: Division of Translational Research

Description: See B4-TBD for program description.

B4-TBX2 / Integrative Studies of Neurobehavioral Trajectories

Division/Office: Division of Translational Research

Description: See B4-TBX for program description.

Sandeep Kishore

sandeep.kishore@nih.gov
555-555-5555

75-DGD / Developmental Neurobiology Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This Program supports research on the fundamental biological mechanisms of nervous system development. This program is founded upon substantial evidence that subtle alterations during sensitive periods in brain development underlie neuropsychiatric disorders that emerge later in life. The program supports studies of mechanisms underlying cell differentiation and the establishment and maturation of functional circuitry in the developing brain, including disruptions of these mechanisms by risk factors associated with mental illness.

Sarah Leinwand

sarah.leinwand@nih.gov
301-402-3969

75-DGG / Functional Neurogenomics Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This Program supports research examining genes, gene function, and gene regulatory mechanisms in vertebrate and invertebrate model organisms (in vivo and in vitro) relevant to understanding the genetic, epigenetic, and genomic components of brain function. This includes studies exploring the genetics and genomics underlying the basic molecular, cellular, and circuit neurobiology of behaviors related to mental health.

David Leitman

david.leitman@nih.gov
301-827-6131

A2-AIA1 / Anxiety Disorders Research Program

Division/Office: Division of Translational Research

Description: See A2-AIA for program description.

A2-AID1 / Mood Disorders Research Program

Division/Office: Division of Translational Research

Description: See A2-AID for program description.

A2-AISN / Social Neuroscience and Communication in Adult Psychopathology

Division/Office: Division of Translational Research

Description: This program supports interdisciplinary research on the biological and behavioral underpinnings of social processes and their abnormalities in psychiatric disorders. The goals of this program are to characterize impairments in social cognition, communication and social functioning in mental disorders, as well as to develop and test novel treatment or intervention targets for said impairments. Ultimately, this program seeks to channel basic scientific knowledge of social processes into greater clinical understandings and novel treatment avenues.

A2-AISZ1 / Psychotic Disorders Research Program

Division/Office: Division of Translational Research

Description: See A2-AISZ for program description.

Christina Liu

christina.liu@nih.gov
301-827-9193

D1-INNP / Program in Non-Human Primates

Division/Office: Division of Data Science and Technology

Description: The Program in Non-Human Primates supports breeding colonies and coordinating centers that provide non-human primates to the research community. This program includes appropriate informatics activities to maintain information about available animals (demographics, kinship data, genomic data, experimental history, and other data points) and provide a way for researchers to request tissues.

D1-INSI / Program in Shared Instrumentation

Division/Office: Division of Data Science and Technology

Description: The Program in Shared Instrumentation supports applications that provide instrumentation to groups of investigators. These awards typically use the S10 activity code (or related codes). Generally, the awards in this portfolio provide only the instrument and does not provide personnel to operate the equipment.

D2-TD / Technology Development Branch

Division/Office: Division of Data Science and Technology

Description: The Technology Development Branch manages tool and technology development applications assigned to NIMH. The branch also is responsible for many informatics research activities assigned to NIMH including data archives, standards, and software development applications from extramural researchers.

Victor Lushin

victor.lushin@nih.gov
301-827-6280

82-SEQQ / Methodological Research Program

Division/Office: Division of Services and Intervention Research

Description: Supports studies that involve development, testing, and refinement of methodologies and instruments to facilitate research on services for mentally ill persons, including measures of severity of illness, family burden, social support, quality of care, effectiveness of care, direct and indirect cost of mental disorders, and short-term and long-term outcome measures; studies submitted by statisticians, psychometricians, and other experts in research methodology and scientific data analysis for work on the design, measurement, and statistical challenges inherent in conducting mental health services research.

Yael Mandelblat-Cerf

yael.mandelblat-cerf@nih.gov
301-793-7563

73-MC / Molecular and Cellular Neuroscience Research Branch

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This Branch plans, supports, and administers programs of research to elucidate the genetic, molecular, and cellular mechanisms underlying brain development, neuronal signaling, synaptic plasticity, circadian rhythmicity, and the influence of hormones and immune molecules on brain function. Other supported activities are drug discovery, identification of novel drug targets, development of functional imaging ligands, development of imaging probes as potential biomarkers, testing of models for assessing novel therapeutics, and studies of mechanisms of action of therapeutics in animals and humans.

73-MCT1 / Signal Transduction Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: See 73-MCT for program description

Mary Marro

mary.acri@nih.gov
301-910-8230

82-SECH / Child and Adolescent Services Research Program

Division/Office: Division of Services and Intervention Research

Description: This program includes research on the quality, organization, and content of services for children with mental disorders and their families. The program focuses on child mental health services provided in multiple sectors and settings, such as schools, primary care, child welfare, juvenile justice, and mental health.

Shahrzad Mavandadi

shahrzad.mavandadi@nih.gov
301-827-1167

82-SEHD / Disparities in Mental Health Services Research Program

Division/Office: Division of Services and Intervention Research

Description: This program plans, stimulates, disseminates, and supports research on the complex factors that influence disparities in mental health services, particularly across special population groups such as racial and ethnic groups, as well as women and children, and persons living in rural and frontier areas. The program addresses care delivered in a variety of settings such as the specialty mental health sector, the general medical sector, and community settings (such as schools).

82-SEMS / Systems Research Program

Division/Office: Division of Services and Intervention Research

Description: Supports studies on organization, coordination, and collaboration of mental health and related services both within and across care settings in order to improve mental health outcomes and prevent or treat co-occurring substance abuse, physical problems, and other behavioral health disorders. Service sectors of interest include: the criminal justice system, housing and other social services, community support, post-trauma services, and adult autism services.

82-SEPC / Primary Care Research Program

Division/Office: Division of Services and Intervention Research

Description: This program includes studies on the delivery and effectiveness of mental health services within the general health care sector; recognition, diagnosis, management, and treatment of mental and emotional problems by primary care providers; coordination of general medical care with and referrals to mental health specialists; provision of psychiatric emergency services, consultation/liaison psychiatry, and other psychiatry, psychology, and social work services within the general medical care sector; studies that improve understanding of how best to improve care for people with mental disorders and co-occurring physical conditions.

Douglas Meinecke

dmeineck@mail.nih.gov
301-443-6767

A3-NSM / Molecular and Cellular Psychopathology Program

Division/Office: Division of Translational Research

Description: This program supports research directed toward developing a mechanistic understanding of the neural bases of mental disorders in adults (ages 18+) at the molecular and cellular level. The goal is to reveal how direct and/or indirect alterations of molecular pathways contribute to the genesis of symptoms and alterations in dimensional constructs (RDoC) of mental disorders. Appropriate applications will employ a diverse range of technical and methodological approaches in an effort to elucidate how interactions between genetic mechanisms and molecular pathways contribute to the etiology, pathogenesis and phenotypic expression of adult mental disorders and how this knowledge may be exploited for the identification and development of novel therapeutic targets.

Tatiana Meza-Cervera

tatiana.meza-cervera@nih.gov
301-437-0670

15-DRYM / Youth Mental Health Disparities Research Program

Division/Office: Office of the Director

Description: This program supports research aimed at reducing mental health disparities that impact children and adolescents and transition aged youth from minoritized and underserved populations in the United States. Areas of interest include variations in course, severity, risk and resilience, prevalence and incidence of mental illnesses and access, utilization, quality, and implementation of evidence-based mental health services in the settings in which children live, learn and play. The program leverages collaborations with other NIH Institutes, Centers, Offices and external Agencies with expertise and investments in Children's Mental Health and Health Disparities to maximize the impact of NIMH-supported youth mental health disparities research.

Enrique Michelotti

michelottiel@mail.nih.gov
301-825-3172

73-MCB / Chemical Optimization Resource Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The program supports chemical optimization projects developed in conjunction with the NIH Blueprint Neurotherapeutics Program contract resources.

73-MCM / Molecular Pharmacology Research Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This program supports research aimed at characterizing the molecular properties of novel pharmacological research tools for the study of cells and molecular imaging. Supported research includes studies on the design, synthesis, and characterization of target-selective ligands, the identification and characterization of compounds derived from natural products, molecular modeling and computational chemistry, the isolation and characterization of endogenous ligands, and the development and evaluation of novel chemical delivery systems.

Dawn Morales

dawn.morales@nih.gov
301-827-9668

15-DRRP / Disparities among Rural Populations Research Program

Division/Office: Office of the Director

Description: This program supports research aimed at strategies to reduce mental health disparities, promote capacity-building, and enhance research infrastructure development in rural and American Indian/Alaska Native populations. Areas of interest include variations in incidence, prevalence, and course of mental disorders and access to care among American Indian/Alaska Native and rural populations, research focusing on the critical roles of context and socioeconomic status on the development of neuropsychiatric disorders, and strategies for reducing mental health disparities.

Sarah Morris

morrisse@mail.nih.gov
301-443-9233

A2-AI / Adult Psychopathology and Psychosocial Interventions Development Branch

Division/Office: Division of Translational Research

Description: This branch promotes translational research that is directed toward advancing discoveries from basic (non-clinical) research into improved understanding of clinical problems and the development and testing of new behavioral, cognitive, and psychosocial interventions. The goals of this work include improving our understanding of how the development, onset, and course of adult psychopathology may be explained by dysfunction in fundamental neurobehavioral mechanisms such as emotion, cognition, motivation and social processes. The branch supports research on modifiable risk and protective factors for psychopathology and on the use of modern psychometric techniques to guide refinements in the conceptualization and assessment of disorder. Emphasis is placed on studies that combine approaches from neuroscience and behavioral science to produce integrative models of risk, disorder, and recovery, consistent with the Research Domain Criteria framework. http://www.nimh.nih.gov/research-priorities/rdoc/index.shtml

A2-AIA2 / Anxiety Disorders Research Program

Division/Office: Division of Translational Research

Description: See A2-AIA for program description.

A2-AID2 / Mood Disorders Research Program

Division/Office: Division of Translational Research

Description: See A2-AID for program description.

A2-AISZ / Psychotic Disorders Research Program

Division/Office: Division of Translational Research

Description: This program supports research into the origins, onset, course, and outcome of schizophrenia spectrum disorders and other psychotic psychopathology. The goals of the program are to discover mechanisms that transform vulnerability characteristics into active illness; to identify valid markers of illness onset; to develop psychometrically sound methods for assessing the cognitive, affective, and behavioral response systems believed to underpin clinical symptoms and functional impairments; and ultimately to channel scientific findings from each of these areas into the development of effective methods of mental illness prevention, treatment, and rehabilitation.

Eric Murphy

eric.murphy@nih.gov
301-443-9230

B4-TBD / Depression and Suicide Related Behaviors Program

Division/Office: Division of Translational Research

Description: This program supports research on the neurodevelopmental trajectories and mechanisms of mental illness associated with affect regulation, emotion, and stress reactivity, including depression, non-suicidal self-injury, suicidal thoughts and behaviors, and related phenotypes in children and adolescents. Of interest are studies that examine the developmental course of, periods of vulnerability or sensitivity for, or risk processes related to the onset, progression, recurrence, and remission of these disorders and their relevant components. Of particular interest are studies that link brain development with behavioral development; studies that identify sensitive periods for typical and atypical developmental trajectories; studies that elucidate biomarkers and mechanisms of disease progression; studies delineating mechanisms of sex and gender differences in the development of these phenotypes; and studies that test integrative models incorporating multiple levels of analysis (biological, behavioral and environmental) across multiple RDoC constructs.

Laurie Nadler

lnadler@mail.nih.gov
301-443-3678

73-MCN / Neuropharmacology Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This program supports research aimed at understanding the cellular and molecular mechanisms of action of psychotherapeutic agents in vitro and in vivo and identifying novel targets for therapeutic intervention in the treatment of mental disorders. Supported research includes studies of the regulation of CNS receptors, transporters, ion channels, neuropeptides, and neuromodulators; investigations into sites and mechanism of action, pharmacokinetics, and effects of psychoactive agents in the brain and other biological systems; and studies on the action of chronic psychoactive drugs on gene expression and function.

Stephen O'Connor

stephen.o'connor2@nih.gov
301-480-8366

85-TPSP / Interventions to Prevent Suicide Research Program

Division/Office: Division of Services and Intervention Research

Description: The portfolio includes youth and adult-related interventions to reduce suicide ideation, attempts and deaths, ranging from exploratory/feasibility studies to effectiveness research. Enhanced approaches to detection, screening, assessment, intervention, follow-up/relapse prevention, as well as types of prevention (universal, selected, indicated) are included. Intervention efforts that address the potential scope of suicide burden (ideation, attempts and/or deaths) or related outcomes (other sources of mortality; functioning) in particular settings, or communities, are encouraged.

Jennifer Pacheco

jennifer.pacheco@nih.gov
301-443-3645

B4-TBB / Attention Deficit, Disruptive Behaviors, and Disorders of Behavioral Dysregulation

Division/Office: Division of Translational Research

Description: This program supports research on ADHD, conduct disorder, oppositional defiant disorder, and other disruptive or repetitive behaviors (e.g. Tourette syndrome). A primary emphasis of this program are studies which recognize heterogeneity within traditional clinical disorders and aim to identify predictive and stable biotypes using a Research Domain Criteria (RDoC) research framework that links behavioral patterns and clinical symptoms to functional domains, neural circuits and physiological processes. Studies which explore the interaction of multiple functional domains or circuits are welcome (e.g., studies examining the interplay of cognitive control, reward processes, and/or emotion regulation). Of interest are studies that examine the developmental course of, periods of vulnerability or sensitivity for, or risk processes related to the onset, progression, recurrence, and remission of these disorders and their relevant components. Of particular interest are studies that link brain development with behavioral development, studies that identify biomarkers for disease progression, and studies that test integrative models incorporating biological, behavioral, and environmental/experiential factors.

David Panchision

panchisiond@nih.gov
301-402-3969

75-DG / Developmental and Genomic Neuroscience Research Branch

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This branch supports fundamental neuroscience research to define the developmental processes and genomic regulatory mechanisms that underlie neural organization, function and plasticity in the brain, particularly as they relate to cognitive, affective and social domains of brain function. Within this context, the branch supports basic functional genomic and developmental studies of genes and allelic variation that have been associated with mental illness risk at genome-wide significance and for which the fundamental biology of those genes is poorly understood. Programs in this branch also support the utilization of research tools and reference data developed through the BRAIN Initiative toward addressing these basic science questions. Approaches can include in vivo, in situ and in vitro paradigms using vertebrate or invertebrate model organisms and human cell-based assays.

75-DGS / Stem Cellular Assay Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This Program supports the optimization and implementation of innovative stem cell-based assays for novel biological readouts and mechanisms relevant to mental disorders. Key components of the program include support for: [1] production and dissemination of human donor-derived resources such as hiPSCs; [2] technology development directed at improving physiological fidelity, technical rigor and scalability of human cell-based assays; and [3] implementation of assays for biological discovery of disease-relevant developmental mechanisms.

Jonathan Pevsner

jonathan.pevsner@nih.gov
301-496-4000

74-GR / Genomics Research Branch

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Genomics Research Branch plans, supports, and administers programs of research including the identification, localization, and functional analysis of genes and other genomic elements that confer susceptibility to mental disorders and their related phenotypes and underlying biological processes. Areas supported by this program include, but are not limited to: ? Studies using genetic and molecular epidemiologic methods to identify genetic, genomic and environmental risk factors underlying the etiology of mental disorders and their related phenotypes and underlying biological processes. ? Identification, localization and function of genes and other genomic elements that confer susceptibility to mental disorders and related dimensional phenotypes ? Translational genetic studies including epigenomics, non-coding functional elements, and integration of multidimensional data to computationally and functionally validate potential underlying networks that lead to disease. ? Development of novel statistical and bioinformatics tools that aim to overcome the unique challenges of elucidating the biological basis of brain disorders. ? Collection and genomic characterization of diverse ancestral populations to expand the NIMH Genetics Initiative

74-GRE / Genetic and Molecular Epidemiology of Mental Disorders

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This program supports research using genetic and molecular epidemiologic methods to explore and catalogue the genetic and genomic factors underlying the etiology of mental disorders at a population level and/or in families, as well as, the exposures that influence variations in the penetrance and expressivity of these factors. This includes efforts to understand the spectrum of phenotypes that are co-morbid and co-heritable with neuropsychiatric disorders. Areas of emphasis include large population-based studies, especially using national registries, large biobanks, longitudinal/birth cohorts and/or broad collection from health care systems. This program also supports NIMH Biorepository and Genomics Resource (see https://www.nimhgenetics.org/), which serves all of NIMH grantees to support the continuing collection of biosamples (blood, DNA, cell-lines, etc.) for mental health research.

74-GRM / Genetic Basis of Mental Disorders Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This program supports research on the identification, localization and function of genes and other genomic elements that confer susceptibility to mental disorders and related dimensional phenotypes (including autism spectrum disorder, attention-deficit hyperactivity disorder, bipolar disorder, depressive disorders, eating disorders, obsessive-compulsive disorder or other anxiety disorders, panic disorder, schizophrenia or other psychotic disorders, personality disorders, post-traumatic stress syndrome, and Tourette syndrome). Areas of emphasis include discovery using whole genome approaches in large case control cohorts or well characterized multiplex family collections or trio designs for detection of de novo events.

74-GRR / Genetics and Genomic Research Resources Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: Collection and genomic characterization of diverse ancestral populations to expand the NIMH Genetics Initiative. This program also supports the development and distribution of novel computational, statistical and other bioinformatics tools for the analysis of genetic and genomic data in psychiatric genetics.

Courtney Pinard

courtney.pinard@nih.gov
301-451-8306

7K-TGDGF / Fellowships — Developmental and Genomic Neuroscience Research

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This program supports fellowships in Developmental and Genomic Neuroscience Research.

7K-TGGRF / Fellowships — Human Genomics Research

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports fellowships in Human Genomics Research.

7K-TGMCF / Fellowships — Molecular, Cellular, and Genomic Neuroscience Research

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports fellowships in Molecular, Cellular, and Genomic Neuroscience Research.

7K-TGNBF / Fellowships — Behavioral Science and Integrative Neuroscience Research

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports fellowships in Behavioral Science and Integrative Neuroscience Research.

Suzy Pollard Branchard

suzy.pollard@nih.gov
301-761-6869

9A-ASGT / Implementation Science to Advance HIV Health Equity

Division/Office: Division of AIDS Research

Description: This program encourages research to enhance the uptake, effectiveness and efficiency of evidence-based interventions, and to inform and enhance the effectiveness and efficiency of interventions currently available in the continuum of HIV prevention, HIV testing, and HIV care, to maximize community impact. Areas of programmatic interest include, but are not limited to: 1) The prevention capacity of systems, providers, or operational tools to target evidence-based interventions (EBIs) to the persons at highest risk for HIV in their communities; 2) The implementation (uptake, effectiveness, efficiency) of individual and/or combination EBIs designed to maximize HIV testing, linkage to HIV care, earlier treatment initiation, adherence and engagement HIV testing, including advancements in approaches and technologies; 3) The impact of varying models of differentiated HIV care on HIV care continuum outcomes, including studies to evaluate optimal approaches to integrate HIV prevention, care, and treatment into community care with related services (mental health, sexually transmitted infections, family planning, prenatal care, malaria, tuberculosis).

Amanda Price

amanda.price@nih.gov
301-435-5224

74-GRT1 / Translational Genomics Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This program supports research that explores the functional role of genomics, beyond the level of DNA variation, in the development of mental disorders. Emphasis in the areas of epigenomics, non-coding functional elements, and integration of multidimensional data to computationally and functionally validate potential underlying networks that lead to disease.

74-GRT2 / Translational Genomics Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This program supports research that explores the role of genomics in the development of mental disorders. Emphasis in the areas of epigenomics, non-coding functional elements, and integration of multidimensional data to computationally and functionally validate potential underlying networks that lead to disease.

Cara Pugliese

cara.pugliese@nih.gov
301-827-2254

85-TPCS / Child and Adolescent Psychosocial Intervention Research Program

Division/Office: Division of Services and Intervention Research

Description: The psychosocial interventions research program supports research evaluating the effectiveness of psychosocial (psychotherapeutic and behavioral) therapeutic interventions, alone or in combination/sequence, on children's and adolescents' mental and behavior disorders, including acute and longer-term therapeutic effects on clinical course and functioning across domains (e.g., school, family, peer functioning).

Mauricio Rangel Gomez

mauricio.rangel-gomez@nih.gov
240-410-7547

72-NBM / Substrates of Memory and Learning Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Program supports relevant basic research on the fundamental mechanisms underlying memory and learning from the behavioral, systems, and cellular perspectives in humans and animals. Deficits in memory and learning function are key features of many psychiatric disorders and improving memory and learning ability are important objectives for therapies addressing mental disorders. Areas of interest include: How is memory consolidated? What neural systems support this process? What mechanisms underlie how memories or previously learned phenomena are recalled, forgotten or extinguished? What processes are involved in the reconsolidation of memories?

Vasudev Rao

vasudev.rao@nih.gov
301-825-3259

9A-ASBZ / HIV Small Business Innovation Research Program and Small Business Technology Transfer Program

Division/Office: Division of AIDS Research

Description: The Small Business Innovation Research Program (SBIR) supports research by small businesses to develop innovative technologies with high potential to succeed commercially or to provide significant societal benefit. The Division's Small Business Technology Transfer Program (STTR) pursues the same objectives with academic research involvement. The SBIR and STTR programs in DAR support research aimed at changing risky behaviors, promoting strategies to reduce HIV transmission, elucidating the pathophysiology of HIV-related neuropsychiatric dysfunction, and investigating processes that influence adherence to treatment in individuals with HIV and mental disorders.

9A-ASBZ1 / Small Business Innovation Research Program and Small Business Technology Transfer Program for Therapeutic Development

Division/Office: Division of AIDS Research

Description: The Small Business Innovation Research Program (SBIR) supports research by small businesses to develop innovative technologies with high potential to succeed commercially or to provide significant societal benefit. The Division's Small Business Technology Transfer Program (STTR) pursues the same objectives with academic research involvement. The SBIR and STTR focus within this program is directed toward the development of new preclinical therapeutics to prevent or treat the neurological consequences of HIV infection.

9A-ASNK / HIV-NeuroAIDS Therapeutics Program

Division/Office: Division of AIDS Research

Description: This program supports bench to bedside research for developing novel drug therapies for the treatment of neurologic and neurocognitive complications of HIV infection. The program supports: (1) preclinical to clinical research on existing and novel drug targets; (2) development of novel approaches for delivering drugs, including antiretrovirals to the central nervous system (CNS); and (3) creative and original research that has as its goal the movement of new treatments and therapeutic strategies to the clinic. In addition, the program encourages basic and clinical studies on neurotoxicities related to high active antiretroviral therapy.

9A-ASNP / Mechanisms of HIV Neuropathogenesis Program

Division/Office: Division of AIDS Research

Description: This program supports basic research to determine the mechanisms of neuropathogenesis caused by HIV and associated opportunistic and co-infections in both the developed and developing world. The program encourages HIV neuropathogenesis research that utilizes state-of-the art approaches derived from the fields of molecular biology, physiology, virology, neurology, immunology, neuropsychology and epidemiology.

Mary Rooney

mary.rooney@nih.gov
301-827-1325

85-TPP / Preventive Interventions Research Program

Division/Office: Division of Services and Intervention Research

Description: Areas of program responsibility include studies evaluating the effectiveness of preventive interventions, including those designed to reduce the occurrence of mental disorders, dysfunctions and related problems within asymptomatic and subclinical populations and those related to treatment (such as prevention of relapse, recurrence, inappropriate resource use) or side effects in children, adolescents and adults.

Andrew Rossi

rossia@mail.nih.gov
301-443-1576

72-NBX / Executive Functions Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Program supports basic research on multiple aspects of cognition, and executive functions in particular. Complex categorization processes, action planning/monitoring, decision making, and cognitive control are all areas of significant interest to the NIMH and this program in particular. Higher-level attentional and perceptual processes are important to understand because they are fundamental building blocks of more complex cognitive functions

Laura Rowland

laura.rowland@nih.gov
301-480-8335

A3-NSI1 / Brain Circuitry and Dynamics Program

Division/Office: Division of Translational Research

Description: See A3-NSI for program description.

A4-GPB1 / Behavioral Science of Mental Disorders and Aging Program

Division/Office: Division of Translational Research

Description: See A4-GPB for program description.

A4-GPT / Neuroscience of Mental Disorders and Aging Program

Division/Office: Division of Translational Research

Description: This program supports studies of neurobiological factors and pathways that may influence the risk, presentation, course, and outcome of mental disorders in late life or in relation to the aging process. There is particular interest in supporting research consistent with NIMH?s emphasis on taking a dimensional and trans-diagnostic approach in studies of psychopathology, as articulated in the Institute?s Research Domains Criteria (RDoC) project. Relevant research typically uses the theories and tools of basic and translational neuroscience and related biological sciences to investigate the pathophysiology of mental disorders or dimensions of psychopathology, but also may involve other, more phenotypically oriented methods so as to examine the key variables across multiple levels of analysis. The integration of measures drawn from theories and research on the biological aging process so as to study the interplay of aging with mechanisms of psychopathology is highly encouraged. The studies supported may include middle-aged or younger patients as well as older adults when there is a major focus on questions pertaining to the aging process, such as in research on the trajectories of mental disorders with aging.

Matt Rudorfer

mrudorfe@mail.nih.gov
301-443-1111

85-TPAP / Adult Psychopharmacology, Somatic, and Integrated Treatment Research Program

Division/Office: Division of Services and Intervention Research

Description: Areas of program responsibility include research involving psychotropic medications (singly or in combination) and somatic treatments of demonstrated efficacy. In addition to established brain stimulation approaches, such as electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS), other nonpharmacologic interventions, such as bright light, physical exercise, and complementary/alternative techniques, for which efficacy has been demonstrated are also of interest. Integrated treatment studies, utilizing combined or sequential treatment approaches to improve long-term outcome and optimize the benefit: risk ratio may entail all efficacious pharmacologic, psychosocial, and somatic interventions.

85-TPAP1 / Adult Psychopharmacology, Somatic, and Integrated Treatment Research Program

Division/Office: Division of Services and Intervention Research

Description: See 85-TPAP for program description.

85-TPCP / Child and Adolescent Psychopharmacology and Integrated Treatment Research Program

Division/Office: Division of Services and Intervention Research

Description: Areas of program responsibility include evaluation of the effectiveness and safety of pharmacological treatments for children and adolescents with mental disorders, and all research that integrates different treatment modalities into combined or sequential interventions, or evaluate the comparative effectiveness of different modalities of treatment.

Jonathan Sabbagh

jonathan.sabbagh@nih.gov
301-594-2557

A3-NSET / Experimental Therapeutics Program

Division/Office: Division of Translational Research

Description: This program supports research that seeks to identify and validate targets for intervention development; assess mechanisms of action of putative interventions; identify and validate biomarkers of disease progression and treatment response; demonstrate and evaluate target engagement of proposed interventions; and evaluate their clinical efficacy. The overall goal is to facilitate the development of novel treatments for major mental disorders in adults (ages 18+) and clinical dimensions of psychopathology associated with these disorders.

Lori Scott-Sheldon

lori.scott-sheldon@nih.gov
301-792-2309

9A-ASP / HIV Data Science, Developmental, Social, and Translational Research Branch

Division/Office: Division of AIDS Research

Description: This Branch supports basic behavioral and social science research, as well as the discovery, development, and testing of novel interventions needed to advance HIV prevention and care. Research focus is encouraged on most at-risk populations and minority communities throughout the lifecycle, with particular interest in pediatric, adolescent, and aging populations. The Branch also supports epidemiological and modeling research, as well as the use of Big Data approaches that may identify or experimentally modify factors that impact HIV acquisition, HIV engagement in care and HIV outcomes.

9A-ASPD / Communication, Dissemination, and Engagement Research Program for the Prevention, Treatment and Cure of HIV

Division/Office: Division of AIDS Research

Description: This program supports communication, dissemination and engagement research to advance HIV prevention, treatment and cure. The overall goal of this program is to maximize the benefits of basic and behavioral scientific discovery in HIV and mental health, by bridging the gap between communication, dissemination, practice and policy. This program also aims to advance our understanding of effective methods for strategic communication, dissemination and engagement at different stages of the HIV care continuum in vulnerable populations. The program encourages (1) studies to understand the impact of targeted communication efforts, social marketing campaigns, and other forms of health messaging on engagement, (2) research on digital technologies and new media platforms designed to achieve impact and reduce health and information disparities, (3) studies of effective communication practices between patients and providers, across health systems and through formal and informal care networks, (4) research on the impact of misinformation or poorly delivered communication, and its contribution to stigma, racism, sexism, xenophobia and other forms of discrimination that impact mental health and HIV outcomes, (5) studies to evaluate research partnerships for learning, knowledge-exchange and knowledge-utilization, across a variety of contexts and community-based settings, and (6) research to elucidate how communication strategies, message framing, and information-dissemination approaches related to HIV, influence and inform other health communication efforts.

9A-ASPI / Methodology and Data-Science of Behavior in HIV Program

Division/Office: Division of AIDS Research

Description: This program supports research studies that advance methodological and data-analytic approaches to collect, integrate, estimate and/or analyze HIV-related data that contain mental health, psychosocial, neurocognitive, and or neurologic measures. This program also supports approaches to identify new factors or combination of factors that may lead to the development of novel HIV-related insights and interventions.

Teri Senn

teri.senn@nih.gov
301-605-4146

9A-ASGP / Psychosocial Comorbidities of HIV Prevention and Treatment

Division/Office: Division of AIDS Research

Description: This program supports research to understand and address the determinants This program supports research on the impact of HIV-related psychosocial co-morbidities, including mental health, stress, and trauma, on HIV prevention, HIV treatment, and HIV-related health outcomes. Research is encouraged that aims to understand the complex interplay among these psychosocial comorbidities, as well as their impact on (a) HIV prevention (behavioral and biomedical) among groups at high risk of HIV infection, (b) the HIV continuum of care (HIV testing, linkage to and retention in care, medication adherence) and (c) health outcomes among individuals infected with HIV (viral load suppression, HIV-related morbidities, mortality). Mental health is broadly defined, and may include, but is not limited to, depression, anxiety, post-traumatic stress disorder, or severe mental illness. Stressful or traumatic life experiences may include childhood maltreatment (e.g., child sexual or physical abuse, child neglect), intimate partner violence, non-partner sexual assault, community violence, or war-related trauma.

Joel Sherrill

jsherril@mail.nih.gov
301-443-2477

85-TPAS / Adult Psychosocial Interventions Research Program

Division/Office: Division of Services and Intervention Research

Description: The psychosocial interventions research program supports research evaluating the effectiveness of psychosocial (psychotherapeutic and behavioral) therapeutic interventions, alone or in combination/sequence, on adults? clinical course and functioning across domains (e.g., social/interpersonal, vocational functioning).

Belinda Sims

belinda.sims@nih.gov
301-435-7155

8K-RT / Office of Research Training and Career Development

Division/Office: Division of Services and Intervention Research

Description: This Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in areas relevant to the focus of the Division. This includes research training and early career development in preventive and treatment interventions, including optimizing, personalizing, and testing the efficacy and effectiveness of mental health interventions; improving use, delivery, and equity of mental health services in traditional and non-traditional health care, and community settings; developing research methodology and analytic procedures related to interventions and services research; and clinical epidemiology. Research that addresses mental health disparities (including in rural populations) is a cross-cutting area of interest in the division.

8K-RTFSC / Fellowships — Child and Adolescent Services Research and Clinical Epidemiology

Division/Office: Division of Services and Intervention Research

Description: This program supports research training at the pre-doctoral and post-doctoral levels of career development in areas relevant to child and adolescent services research and clinical epidemiology.

8K-RTFSL / Fellowships — Lifespan Services Research and Clinical Epidemiology

Division/Office: Division of Services and Intervention Research

Description: This program supports research training at the pre-doctoral and post-doctoral, levels of career development in areas that span child and adolescent, and adult services research and clinical epidemiology, for example adolescents and young adults.

8K-RTFTC / Fellowships — Child and Adolescent Treatment and Preventive Intervention Research

Division/Office: Division of Services and Intervention Research

Description: This program supports research training at the pre-doctoral and post-doctoral levels of career development in areas relevant to child and adolescent treatment and preventive intervention research.

8K-RTFTL / Fellowships — Lifespan Treatment and Preventive Intervention Research

Division/Office: Division of Services and Intervention Research

Description: This program supports research training at the pre-doctoral and post-doctoral levels in areas that span child and adolescent, and adult treatment and preventive intervention research and clinical epidemiology, for example adolescents and young adults.

8K-RTID / Institutional — Services, Treatment, and Preventive Intervention Research

Division/Office: Division of Services and Intervention Research

Description: This program supports institutional research training and research education at the pre-doctoral and post-doctoral levels, and early investigator level of career development in areas that span services, treatment, and preventive intervention research.

8K-RTIS / Institutional — Services Research and Clinical Epidemiology

Division/Office: Division of Services and Intervention Research

Description: This program supports institutional research training and research education at the pre-doctoral and post-doctoral levels, and early investigator level of career development in areas relevant to services research and clinical epidemiology research.

8K-RTIT / Institutional — Treatment and Preventive Intervention

Division/Office: Division of Services and Intervention Research

Description: This program supports institutional research training and research education at the pre-doctoral and post-doctoral levels, and early investigator level of career development in areas relevant to treatment and preventive intervention research.

8K-RTTSC / Training — Child and Adolescent Services Research and Clinical Epidemiology

Division/Office: Division of Services and Intervention Research

Description: This program supports research and training at the pre-doctoral and post-doctoral, and early investigator level of career development in child and adolescent services research and clinical epidemiology.

8K-RTTSL / Training — Lifespan Services Research and Clinical Epidemiology

Division/Office: Division of Services and Intervention Research

Description: This program supports research and training at the pre-doctoral and post-doctoral, and early investigator level of career development in areas that span child and adolescent, and adult services research and clinical epidemiology, for example adolescents and young adults.

8K-RTTTC / Training — Child and Adolescent Treatment and Preventive Research

Division/Office: Division of Services and Intervention Research

Description: This program supports research and training at the pre-doctoral and post-doctoral, and early investigator level of career development in child and adolescent treatment and preventive intervention research.

8K-RTTTL / Training — Lifespan Treatment and Preventive Intervention Research

Division/Office: Division of Services and Intervention Research

Description: This program supports research and training at the pre-doctoral, post-doctoral, and early investigator levels of career development in areas that span child and adolescent, and adult treatment and preventive intervention research, for example adolescents and young adults.

Abigail Soyombo-Shoola

abigail.soyombo@nih.gov
301-827-7329

D1-IN / Infrastructure Branch

Division/Office: Division of Data Science and Technology

Description: The Program in Tissue and BRAIN Banks supports infrastructure related to providing infrastructure related to tissue and BRAIN banks. These awards provide tissues to approved members of the research community. Awards often have an informatics component to maintain information about available tissues and to provide a way for researchers to request tissues. Tissues can come from one or multiple species.

D1-INTB / Program in Tissue and BRAIN Banks

Division/Office: Division of Data Science and Technology

Description: The Program in Tissue and BRAIN Banks supports infrastructure related to providing infrastructure related to tissue and BRAIN banks. These awards provide tissues to approved members of the research community. Awards often have an informatics component to maintain information about available tissues and to provide a way for researchers to request tissues. Tissues can come from one or multiple species.

Anais Stenson

anais.stenson@nih.gov
240-926-7572

9A-ASPC / Clinicial Neuroscience of HIV Infection Program

Division/Office: Division of AIDS Research

Description: This program supports clinical neuroscience research on infants, children, adolescents, adults and the aging who are HIV infected or at risk for acquiring HIV. Specifically, the program encourages studies addressing neurocognitive, behavioral, and psychiatric consequences of living with HIV across the lifespan -- as well as factors that may modify the risk for, or the manifestation of, these consequences. In addition, the program encourages studies that utilize neuroscience and basic behavioral research-based approaches to optimize HIV prevention and treatment.

9A-ASPQ / Human Mobility and HIV Program

Division/Office: Division of AIDS Research

Description: This program supports research on the impact of human mobility on prevention and treatment outcomes in individuals at risk or living with HIV (PLWH). Human mobility is broadly defined as human movement, as individuals or groups, in space and time and includes, among others livelihood mobility, displacement, household fluidity, rural to urban migrations, and involuntary mobility such as being trafficked for sexual exploitation. The purpose of this program is to advance our understanding of how human mobility affects (dis)engagement with the HIV prevention and care cascade and to develop strategies to address these challenges.

Mike Stirratt

stirrattm@mail.nih.gov
240-627-3875

9A-ASGA / Adherence to HIV Treatment and Prevention Program

Division/Office: Division of AIDS Research

Description: This program supports scientific research in four domains: (1) adherence to biomedical HIV prevention methods [e.g., pre-exposure prophylaxis (PrEP)]; (2) initiation of antiretroviral therapy when indicated for HIV treatment; (3) adherence to antiretroviral therapy for HIV treatment; and (4) retention in HIV primary medical care. Within these areas, the program supports studies to inform future interventions, develop and test novel interventions, and advance the dissemination and implementation of proven interventions. Intervention research may target individuals, providers, or healthcare systems and policies. The program invites research conducted in U.S. domestic settings or international settings that have high HIV incidence or prevalence, with an emphasis on approaches likely to have broad impact.

Maggie Sweeney

maggie.sweeney@nih.gov
301-480-1582

8K-RTFSA / Fellowships — Adult Services Research and Clinical Epidemiology

Division/Office: Division of Services and Intervention Research

Description: This program supports research training at the pre-doctoral and post-doctoral levels of career development in areas relevant to adult services research and clinical epidemiology.

8K-RTFTA / Fellowships — Adult Treatment and Preventive Intervention Research

Division/Office: Division of Services and Intervention Research

Description: This program supports research training at the pre-doctoral and post-doctoral levels of career development in areas relevant to adult treatment and preventive intervention research.

8K-RTTSA / Training- Adult Services Research and Clinical Epidemiology

Division/Office: Division of Services and Intervention Research

Description: This program supports research and training at the pre-doctoral and post-doctoral, and early investigator level of career development in adult services research and clinical epidemiology.

8K-RTTTA / Training — Adult Treatment and Preventive Intervention Research

Division/Office: Division of Services and Intervention Research

Description: This program supports research and training at the pre-doctoral and post-doctoral, and early investigator level of career development in adult treatment and preventive intervention research.

8T-SB1 / Small Business Innovation Research Program and Small Business Technology Transfer Program

Division/Office: Division of Services and Intervention Research

Description: See 8T-SB for program description.

Alexander Talkovsky

alexander.talkovsky@nih.gov
301-827-7614

A2-AIA / Anxiety Disorders Research Program

Division/Office: Division of Translational Research

Description: This program supports translational research on the etiology, core features, course, assessment, treatment, and prevention of anxiety disorders, including research aiming to improve understanding of their common and distinguishing features. It emphasizes a mechanistic, dimensional approach to psychopathology as outlined in the RDoC initiative and experimental therapeutics model. Ultimately, this program?s mission is to translate basic science and neuroscience into improved models, assessments, and treatments for prevention and intervention leading to significant public health impact.

A2-AID / Mood Disorders Research Program

Division/Office: Division of Translational Research

Description: This program supports translational research on the etiology, core features, course, assessment, treatment, and prevention of mood disorders, including research aiming to improve understanding of their common and distinguishing features. It emphasizes a mechanistic, dimensional approach to psychopathology as outlined in the RDoC initiative and experimental therapeutics model. Ultimately, this program?s mission is to translate basic science and neuroscience into improved models, assessments, and treatments for prevention and intervention leading to significant public health impact.

A2-AISZ2 / Psychotic Disorders Research Program

Division/Office: Division of Translational Research

Description: See A2-AISZ for program description.

Laura Thomas

laura.thomas@nih.gov
301-480-1624

B4-TBA / Anxiety and Related Disorders of Behavioral Dysregulation

Division/Office: Division of Translational Research

Description: This program supports research on the neural mechanisms and trajectories of anxiety disorders and associated disorders of behavioral dysregulation during development. The program supports research on a range of clinical symptoms and phenotypes including anxiety disorders (e.g., generalized anxiety disorder, social anxiety disorder, specific phobias, panic disorder, agoraphobia, separation anxiety disorder, selective mutism), obsessive-compulsive disorder, eating disorders (e.g. anorexia nervosa, bulimia nervosa, binge eating disorder), and related phenotypes and prodromes. Of interest are studies that examine the etiology, neurodevelopmental mechanisms, developmental course of, periods of vulnerability or sensitivity for, or risk processes related to the onset, progression, recurrence, and remission of these disorders and their relevant components. Of particular interest are studies that characterize the developmental trajectories of brain maturation and dimensions of behavior to understand the roots of mental illness; studies that identify sensitive periods for typical and atypical trajectories; studies that elucidate biomarkers and mechanisms of disease progression; studies delineating mechanisms of sex/gender differences in the development of behavioral dysregulation; and studies that test integrative models incorporating multiple levels of analysis and RDoC approaches.

Jessica Tilghman

jessica.tilghman@nih.gov
301-827-0439

A3-NSNM / Neuromodulation and Neurostimulation Program

Division/Office: Division of Translational Research

Description: This program supports research that seeks to refine existing neurostimulation and neuromodulation interventions; identify and validate targets for novel interventions using such modalities; assess mechanisms of action of existing and putative neuromodulation interventions; and identify and validate biomarkers of disease progression and treatment response. The overall goal is to advance neurotherapeutics for major mental disorders and clinical dimensions of psychopathology (RDoC) associated with these disorders.

Leonardo Tonelli

leonardo.tonelli@nih.gov
301-827-8601

73-MCI / Neuroendocrinology and Neuroimmunology Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Neuroendocrinology Program supports fundamental research to elucidate the cellular and molecular mechanisms whereby hormones and hormone receptors, acting through nuclear and membrane receptors, modulate signaling in brain circuits relevant to affect, cognition, and social behavior. The Neuroimmunology Program supports fundamental research to identify mechanisms underlying the effects of immune cells, cytokines, and chemokines on neurodevelopment, signaling cascades, synaptic plasticity, brain circuits, and behaviors related to affect, cognition and social behavior.

Farris Tuma

ftuma@mail.nih.gov
301-443-9232

AD-TS / Traumatic Stress Disorders Research Program

Division/Office: Division of Translational Research

Description: The Traumatic Stress Research Program coordinates research on psychopathology related to trauma, including research on neurobiological, behavioral, cognitive, and other risk and protective factors for psychopathology after traumatic events and the development of interventions for posttraumatic psychopathology. The program also supports research spanning and integrating basic science, clinical practice, and health care system factors regarding mass trauma and violence (e.g., war, terrorism, natural and technological disaster), including translational (basic, clinical, and genomic) research on the mental health consequences of traumatic stress to elucidate the nature, causes, and pathophysiology of posttraumatic psychopathology; the development and testing of interventions to assist victims and survivors at risk for and experiencing posttraumatic psychopathology; and models for delivering care effectively and efficiently across settings, contexts, and populations (e.g., children, adolescents, and adults).

Ashlee Van't Veer

ashlee.vantveer@nih.gov
301-443-3107

7K-TG / Office of Research Training and Career Development

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. The Office thus supports institutional and individual research training programs, research education programs, and early career development programs in basic neuroscience and human genomics.

7K-TGDG / Training — Developmental and Genomic Neuroscience Research

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This program supports research training, research education, and mentored career development award programs in Developmental and Genomic Neuroscience Research.

7K-TGGR / Training — Human Genomics Research

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports research training, research education, and mentored career development award programs in Human Genomics Research.

7K-TGGR1 / Training — Human Genomics Research

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: See 7K-TGGR for program description.

7K-TGMC / Training — Molecular, Cellular, and Genomic Neuroscience Research

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports research training, research education, and mentored career development award programs in Molecular, Cellular, and Genomic Neuroscience Research.

7K-TGMC2 / Training — Molecular, Cellular, and Genomic Neuroscience Research

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: See 7K-TGMC for program description.

7K-TGNB / Training — Behavioral Science and Integrative Neuroscience Research

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports institutional training, research education, and mentored career development award programs in Behavioral Science and Integrative Neuroscience Research.

7K-TGNB1 / Training — Behavioral Science and Integrative Neuroscience Research

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: See 7K-TGNB for program description.

7K-TGRM / Collaborative Research Training

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Research Training and Career Development Office supports research training at the pre-doctoral, post-doctoral, and early investigator level of career development in scientific areas relevant to the focus of the Division. This program supports collaborative research training and career development activities, e.g. NIH Common Fund, NIH BRAIN Initiative, the Neuroscience Blueprint, and other trans-Institute programs.

Siavash Vaziri

siavash.vaziri@nih.gov
301-594-2924

72-NBT / Theoretical and Computational Neuroscience Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Program supports research on the development and application of realistic models for the analysis and understanding of brain function. Project areas include empirical and theoretical studies of self-organizing behavior in neuronal systems, mathematical approaches to modeling non-stationary neuronal processes, functional imaging of dynamical processes, and the modeling of all levels of neuronal processing, from single cell activity to complex behaviors.

72-NBT1 / Computational Cellular Neuroscience and Reward Sys

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This program supports basic experimental and theoretical research focusing on biophysically based, multi-scale computational modeling of cellular and molecular pathways in brain circuits, including those that link cellular and sub-cellular activity to neural systems that underlie complex mental health behaviors. This program supports the overall areas of interest and priorities of the Division of Basic Behavioral Neuroscience. The program encourages data-driven studies that provide models of how molecular and cellular pathways relate to synaptic biophysical models and how these can be used to bridge cellular levels of analysis to circuits and behavior. This program seeks to accelerate development of preclinical therapeutic computational models that modulate electrical and chemical activity in central and peripheral nerves to improve brain function and mental health relevant behaviors.

Vidya Vedham

vidya.vedham@nih.gov
301-555-5555

9G-GMH3 / Global Mental Health Dissemination and Implementation Research Program

Division/Office: Division of AIDS Research

Description: The Center for Global Mental Health Research recognizes the importance of building an evidence base to advance the field of global mental health. Implementation research remains critical for overcoming many global mental health challenges, especially in low-and middle-income country settings. Research is needed to translate evidence into practice and policy, as well as to develop models for scaling up evidence-based interventions to communities and clinical setting and disseminating information to stakeholders, the public, and policymakers. The Global Mental Health Dissemination & Implementation Research Program supports rigorous and relevant research and research training with the goal to optimize implementation science within the field of mental health and population science.

Aleksandra Vicentic

vicentica@mail.nih.gov
301-443-1576

72-NB / Behavioral Science and Integrative Neuroscience Research Branch

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Branch supports innovative research - including empirical, theoretical and modeling approaches - on cognitive, affective, social, motivational, and regulatory systems and their development across the lifespan in humans, in non-human primates, and in other animals. Research approaches looking at the interaction between and among these major systems is of particular interest.

72-NBB / Regulatory and Systems Neuroscience Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: The Program supports research in humans and animals on the fundamental principles and mechanisms of biobehavioral regulation (i.e., the interaction of behavioral and biological processes), including the development, organization and function of neural circuits relevant to understanding the normal functioning of a variety of brain structures. Areas of interest include neural basis and regulation of motivation, reward, fear, stress, anxiety, circadian rhythms, sleep, and arousal.

Andrea Wijtenburg

andrea.wijtenburg@nih.gov
301-480-8177

A3-NSI / Brain Circuitry and Dynamics Program

Division/Office: Division of Translational Research

Description: This program supports research directed toward developing a mechanistic understanding of the brain bases of mental disorders in adults (ages 18+) at the circuit level, drawing heavily on the use of a wide variety of state-of-the-art neuroimaging and other physiological methods, including, but not limited to, those measuring brain dynamics. Applications will generally employ various neuroimaging and/or electrophysiological measures, often in conjunction with cognitive/behavioral neuroscience methodologies, to elucidate how the relevant neural systems contribute to the etiology, pathogenesis and phenotypic expression of adult mental disorders and relate to outcomes and treatment response.

Abera Wouhib

abera.wouhib@nih.gov
301-594-9195

A2-AIC1 / Statistical Methods in Psychiatry Program

Division/Office: Division of Translational Research

Description: The goal is to foster novel statistical methods and analytical plans that identify and statistically validate biomarkers and novel treatment targets corresponding to psychiatric disorders. Exploring parsimonious statistical models, power analyses and analytical strategies and overcome the unique challenges of neuroimaging and psychiatric data. The program is interested in statistically sound novel inferential approaches, efficient methods of designing clinical and/or nonclinical studies suitable to psychiatry with the goal of reducing the burden of mental disorder.

Yong Yao

yyao@mail.nih.gov
301-402-3969

75-DGA / Brain Cellular Atlas and Cellular Census Program

Division/Office: Division of Neuroscience and Basic Behavioral Science

Description: This Program supports optimization and implementation of innovative scalable approaches for large-scale characterization of normative brain cell diversity and anatomical organization underlying brain functions relevant to mental illness. This primarily encompasses studies supported through the BRAIN Initiative on brain cellular makeup and organizational principles conserved across organisms and specialized in individual species

Steven Zalcman

szalcman@mail.nih.gov
301-443-1692

A3-NS / Adult Pathophysiology and Biological Interventions Development Branch

Division/Office: Division of Translational Research

Description: This branch supports programs of research aimed at understanding the brain basis of mental disorders. Specifically supported are multidisciplinary studies with human and model systems on the genetic, molecular, cellular, circuit, and systems levels of brain function designed to elucidate the pathophysiology of mental disease and to translate these findings to clinical diagnosis, treatment, and prevention strategies. These approaches are applied to the entire spectrum of mental disorders.

A3-NSS / Central-Peripheral Interactions Pathophysiology Program

Division/Office: Division of Translational Research

Description: This program supports research directed towards understanding how dysfunction in neural systems and other biological systems contribute to psychopathology and dimensional behavioral disorders in adults (ages 18+). There is an emphasis on the functional relationship between interacting neural circuitries and peripheral biological systems and processes. Key questions include how these interactions contribute to symptoms or dimensional constructs (RDoC) that are characteristic of mental disorders and how such interactions can be exploited for translational therapeutic development. Experimental approaches may include genetic analysis, endocrine function, bioenergetics, animal models, neuroimaging, and molecular approaches.

Julia Zehr

zehrj@mail.nih.gov
301-443-1617

B4-TB / Developmental Mechanisms and Trajectories of Psychopathology Branch

Division/Office: Division of Translational Research

Description: This branch supports research on the developmental mechanisms contributing to mental disorders and on developmental trajectories of risk and resilience. Research supported in this branch identifies mechanisms responsible for mental disorders by looking across levels of analysis to specify genetic, neural, behavioral, and environmental components that interact to define etiology of childhood-onset mental disorders. In addition, research supported in this branch identifies trajectories of mental disorders by looking across time (e.g., across developmental stages) at sequential and integrative relationships among genetic, neural, behavioral, and experiential/environmental factors leading to psychopathology or to recovery. Emphasis is on developmental progressions and the identification of early signs, risk factors, predictors, and biological mediators/moderators of continuity or change. During development, risk factors may contribute to a range of psychopathologies, and early indicators of later risk are often dimensional. Thus, the branch supports research that crosses traditional diagnostic categories, consistent with the NIMH RDoC initiative. This branch strongly encourages cross-disciplinary research collaborations. Studies involving human and non-human animals are supported, focusing on development from the prenatal period through adolescence.

B4-TBX / Integrative Studies of Neurobehavioral Trajectories

Division/Office: Division of Translational Research

Description: This program supports research focused on the interrelations among a broad range of risk processes and phenotypes across time and development, with a particular emphasis on the interaction between experience, biological factors, and development. Of particular interest are studies that examine basic behavioral components that span multiple disorders; studies that link biological and behavioral components of normal and abnormal functioning; and studies of early neurodevelopment and behavior, etiology, biomarkers and assessment that are applicable to multiple forms of psychopathology. The program includes, but is not limited to, research on perinatal contributions to neurodevelopment; the long-term effects of experience and the developmental origins of health and disease; the effects of stress and adversity on brain maturation and risk for psychopathology; and the intersection of physiological and brain development.