Science News About Brain Anatomy and Physiology

An NIMH-funded study identified consistent links between brain connectivity and cognitive function in people with early stage psychosis and people at high risk who later developed psychosis.

A scientific team supported by the National Institutes of Health (NIH) unveiled the first complete map of the neural connections of the common fruit fly brain.

The largest neuroimaging study of conduct disorder to date, with funding from NIH, has revealed extensive changes in brain structure among young people with the disorder. The largest difference was a smaller area of the brain’s outer layer, known as the cerebral cortex, which is critical for many aspects of behavior, cognition and emotion.

In a new neuroimaging study funded by the National Institute of Mental Health, researchers used repetitive transcranial magnetic stimulation to target regions deep in the brain to help reduce depression symptoms.

In this NIMH-supported study, researchers investigated the neural underpinnings of sensory hypersensitivity in SCN2A-associated autism.

Research funded by NIMH found a link between a low level of social interest among people with psychotic disorders and brain regions in the social motivation system.

For the first time ever, an international team of researchers has created a complete cell atlas of a whole mammalian brain.

A group of international scientists have mapped the genetic, cellular, and structural makeup of the human brain and the nonhuman primate brain, allowing for a deeper knowledge of the cellular basis of brain function and dysfunction, helping pave the way for a new generation of precision therapeutics for people with mental disorders and other disorders of the brain.

NIMH-funded research sheds light on how negative early life experiences may impact how we act in response to rewards, which is often disrupted in people with mental illnesses.

New research supported by NIMH used mathematical approaches to explain how neurons in the brain communicate over time to support information processing.

A subset of white blood cells, known as myeloid cells, can harbor HIV in people who have been virally suppressed for years on antiretroviral therapy, according to findings from a small study supported by the National Institutes of Health.

An NIMH-supported study suggests that adolescents living through the COVID-19 pandemic may be experiencing more anxiety and depression symptoms and accelerated brain aging.

The NIMH Healthy Research Volunteer Study aims to build a comprehensive, publicly accessible resource with a range of brain and behavioral data from healthy volunteers.

Scientists have developed a research method that allows for a much more detailed examination of the brain processes involved in some neurological and mental disorders.

The National Institutes of Health has launched two transformative projects supported by the Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative: The BRAIN Initiative® Cell Atlas Network and the Armamentarium for Precision Brain Cell Access.

A recent NIMH-supported study investigated whether deep brain stimulation could be personalized for individuals with treatment-resistant depression.

The NIH Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative Cell Census Network (BICCN) has unveiled an atlas of cell types and an anatomical neuronal wiring diagram for the mammalian primary motor cortex, derived from detailed studies of mice, monkeys, and humans.

A new NIMH-supported study found that eating disorder behaviors alter the brain’s reward response process and food intake control circuitry, which can reinforce the behaviors.

Researchers in the NIMH Intramural Research Program have developed a new way to measure the degree to which the proportions of an individual person’s brain differ from the proportions typically seen in the broader population. This technique yields new insights into brain development and offers tools for further study.

A study of spatial learning in mice shows that exposure to new experiences dampens established representations in the brain’s hippocampus and prefrontal cortex, allowing the mice to learn new navigation strategies.

A genetic study has identified neuronal abnormalities in the electrical activity of cortical cells derived from people with a rare genetic disorder called 22q11.2 deletion syndrome.

A scientific analysis of more than 2,000 brain scans found evidence for highly reproducible sex differences in the volume of certain regions in the human brain.

Researchers funded by NIMH have found that astrocytes, a type of brain cell, can harbor HIV and then spread the virus to immune cells that traffic out of the brain and into other organs.

In a study published in 2019 in the journal Nature Neuroscience, researchers funded by the National Institute of Mental Health investigated the neurobiological changes that occur in the brain circuits of mice when contextual fear memories — fear of a place where an aversive event occurred — are formed and extinguished.

An innovative NIMH-funded trial shows that a receptor involved in the brain’s reward system may be a viable target for treating anhedonia (or lack of pleasure), a key symptom of several mood and anxiety disorders.

NIH-funded research uses machine learning algorithm to predict individual response to a commonly-prescribed antidepressant.

NIH-supported study finds that spatial “replay” in neurons may help rats learn how to navigate toward goals.

The NIH has announced its continued support for the Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative by funding more than 180 new BRAIN Initiative awards, bringing the total 2019 budget for the program to more than $424 million.

Researchers have uncovered sex-based differences in the development of the hippocampus and amygdala—brain areas that have been implicated in the biology of several mental disorders that impact males and females differently.

On April 11-13, 2019, approximately 1,500 scientists from many disciplines will attend the fifth annual Brain Research through Advancing Innovative Neurotechnologies (BRAIN)® Initiative Investigators Meeting in Washington, DC. This open meeting provides a forum for discussing scientific developments and potential new directions, and to identify areas for collaboration and research coordination.

Researchers have identified changes in brain connectivity and brain activity during rest and reward anticipation in children with anhedonia, a condition where people lose interest and pleasure in activities they used to enjoy.

Researchers have shown that a type of magnetic resonance imaging — called neuromelanin-sensitive MRI (NM-MRI) — is a potential biomarker for psychosis. NM-MRI signal was found to be a marker of dopamine function in people with schizophrenia and an indicator of the severity of psychotic symptoms in people with this mental illness.

A new study in rodents has demonstrated, for the first time, that the brain’s cerebellum plays a role in controlling reward and social preference behavior—findings that shed light on the brain circuits critical to the affective and social dysfunction seen across multiple psychiatric disorders.

In a new study, researchers have traced the brain pathways responsible for the effects of light on learning and mood. The findings revealed that these effects are brought about by two different and distinct pathways from the retina into the brain.

A new study has revealed more about the organization and function of a brain structure—the paraventricular nucleus of the thalamus—that may serve a key role in linking stress detection to the development of adaptive behaviors.

People infected with the human immunodeficiency virus, known as HIV, display reductions in brain volume compared with people who are not infected with HIV, but now an NIMH-funded study has shed light on the course of this deterioration and shows that antiretroviral treatment started in the first few years of infection may stop these brain changes.

The National Institutes of Health released to the scientific community an unparalleled dataset from the Adolescent Brain Cognitive Development (ABCD) study.

Star-shaped support brain cells, astrocytes, growing in 3-D “organoids” in a dish develop similarly as those in human brain tissue.

The directors of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Institute of Mental Health, and the National Institute of Neurological Disorders and Stroke discuss the importance of post-mortem brain donation in a joint message.

Functional connectivity magnetic resonance imaging (fcMRI) may predict which high-risk, 6-month old infants will develop autism spectrum disorder (ASD) by age 2 years.

Beginning May 31, 2017, the National Institute of Mental Health (NIMH) will launch a speaker series intended to bring together leaders in the field conducting research using non-invasive brain stimulation and functional imaging including EEG, fMRI, and transcranial magnetic stimulation (TMS).

A genetic engineering tool has disentangled seemingly hopelessly intertwined brain circuits for social fear and aggression in mice.

Big data pinpoints genetic variation linked to brain volume and risk for disorders.

The study will follow the biological and behavioral development of more than 10,000 children through adolescence into early adulthood.

Scientists have synthesized a molecule with a unique profile of highly specific pain-relieving properties and demonstrated its efficacy in mice.

Schizophrenia, autism risk gene trajectories point to shared causes

The more folding in the thinking parts of our brain, the smarter we are – to a degree.

Two of the world’s largest brain tissue banks unify efforts to collect and distribute a critical number of brain donations for important autism research.

A drug being studied as a fast-acting mood-lifter restored pleasure-seeking behavior independent of – and ahead of – its other antidepressant effects.

Later evolving and maturing brain areas, which also are those most implicated in mental illness, showed gradually increasing heritability, peaking by late adolescence – the age-of-onset for most mental disorders. New findings hold promise for understanding how age plays an important role in gene-environment interactions that underlie the disorders.

A brain blueprint maps where genes are tuned on and off during mid-pregnancy—when most brain disorders such as autism and schizophrenia occur.

The hippocampus houses learning and memory—specifically the storage of knowledge of who, what, where, and when. Using a special transgenic mouse, researchers have now pinpointed a hippocampal region called CA2 that is important for social memory, the ability of animal to recognize another of the same species. Understanding this region could be useful in understanding and treating disorders characterized by altered social behaviors such as schizophrenia, bipolar disorder, and autism.

NIMH/NICHD experts explain what sparks and halts youth violence.